YN371584 ent-Ezetimibe 1376614-99-1

ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potentNrf2activator.

YN370867 MMPI-1154 1382722-47-5

MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA)MMP-2inhibitor(IC50=6.6μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP...

YN480682 HJC0197 1383539-73-8

HJC0197 is a potentEpac1(exchange protein directly activated by cAMP 1) and Epac2(IC50=5.9μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GD...

YN370366 Tropifexor 1383816-29-2

Tropifexor (LJN452) is a highly potent agonist ofFXRwith an EC50 of 0.2nM.

YN360329 ML277 1401242-74-7

ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270nM. ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCN...

YN350090 (rel)-AR234960 1408311-94-3

(rel)-AR234960 is an active relative configuration of AR234960. AR234960, a non-peptideMAS(a G protein-coupled receptor) agonist, increases both mRNA and protein levels of CTGF via ERK1/2 signaling in HEK293-MAS ...

YN320986 PF-543 Citrate 1415562-83-2

PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitiveSPHK1inhibitor with an IC50 of 2nM and a Ki of 3.6nM. PF-543 Citrate is >100-fold selectivity ...

YN360279 AMG 333 1416799-28-4

AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8.

YN360692 GSK2798745 1419609-94-1

GSK2798745 is a first-in-class, highly potent, selective, orally active transient receptor potential vanilloid 4(TRPV4) ion channelblocker with IC50s of 1.8 and 1.6nM for hTRPV4 and rTRPV4, respectively. GSK2798745 ...

YN481220 (3R,5R)-Rosuvastatin Lacto... 1422954-11-7

(3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.

YN372535 PF-06282999 1435467-37-0

PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases.

YN370108 PF-1355 1435467-38-1

PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases.

YN360531 JTV-519 hemifumarate 1435938-25-2

JTV-519 hemifumarate (K201 hemifumarate) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprote...

YN481635 Ciraparantag 1438492-26-2

Ciraparantag is athrombin and factor Xainhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is report...

YN481636 Ciraparantag TFA 1438492-27-3

Ciraparantag TFA is athrombin and factor Xainhibitor. Ciraparantag TFA is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants....

YN360307 ML67-33 1443290-89-8

ML67-33 is a selective activator of temperature- and mechano-sensitiveK2Pchannels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3μM and 9.7μM in cell-free and HEK293 cells, respectivel...

YN481640 Voxelotor 1446321-46-5

Voxelotor(GBT440, GTx011) is a novel small molecule hemoglobin modifier which increases hemoglobin oxygen affinity.

YN371010 SBI-425 1451272-71-1

SBI-425 is a potent, selective and oral bioavailabletissue-nonspecific alkaline phosphatase (TNAP)inhibitor. Long-term administration of SBI-425 effectively reaches and inhibits TNAP in the vasculature, improving cardiova...

YN410040 SP-8356 1454885-45-0

SP-8356, an anti-inflammatory synthetic Verbenone derivative, is a potent, orally activecluster of differentiation 147 (CD147)inhibitor. SP-8356 inhibits CD147-cyclophilin A (CypA) interaction and reduces MMP-9 activity. S...

YN480576 Endothelial lipase inhibitor-... 1466427-02-0

Endothelial lipase inhibitor-1 is a potentendothelial lipaseinhibitor with an IC50 of 49nM.