YN480408 Fulacimstat 1488354-15-9

Fulacimstat is an orally availablechymaseinhibitor, with IC50s of 4, 3nM for human and hamster chymase enzyme, respectively.

YN440347 UNC2881 1493764-08-1

UNC2881 is a specific Mer tyrosine kinase inhibitor with IC50 of 4.3 nM, about 83- and 58-fold selectivity over Axl and Tyro3, respectively.

YN320398 Relacorilant 1496510-51-0

Relacorilant is a potent, selective and orally bioavailableglucocorticoid receptorantagonist, with a Ki of 7.2nM in HepG2 TAT assay, and also showsKis of 12, 81.2, 210nM for rat, human and monkey glucocorticoid receptor in c...

YN300076 Gap19 1507930-57-5

Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selectiveconnexin 43 (Cx43) hemichannelblocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C...

YN480757 XEN445 1515856-92-4

XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.

YN360644 Etripamil 1593673-23-4

Etripamil (MSP-2017) is a short-actingL-type calcium-channelantagonist, can be used for the research of Paroxysmal Supraventricular Tachycardia (PSVT). Etripamil (MSP-2017) slows atrioventricular nodal conduction and prolo...

YN440369 Alofanib 1612888-66-0

Alofanib(RPT835) is a novel selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect with IC50 <10 nM on FGF2-induced phoshphorylation of FRS2a in KATO III cells. It has no direct effect o...

YN321540 Propranolol D7 hydrochloride 1613439-56-7

Propranolol D7 hydrochloride is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselectiveβ-adrenergic receptor (βAR)antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8n...

YN370260 Desidustat 1616690-16-4

Desidustat (ZYAN1, ZYAN1-1001), an antianaemic drug candidate, is an orally active hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor (HIF-PHI) that stimulates erythropoiesis.

YN480690 Cimlanod 1620330-72-4

Cimlanod (BMS-986231) is a second-generationNitroxyl (HNO)donor for heart failure. Cimlanod (BMS-986231) delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream. Cimla...

YN320397 Praliciguat 1628730-49-3

Praliciguat (IW-1973) is a potent and orally activesoluble guanylate cyclasestimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC50 of 197nM.

YN320399 Olinciguat 1628732-62-6

Olinciguat (IW-1701) is an oralguanylate cyclase(sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.

YN300054 GSK 3008348 hydrochloride 1629249-40-6

GSK 3008348 hydrochloride is a small molecule integrin αvβ6 antagonist, extracted from patent WO/2014154725A1, example 1. The affinity (pIC50) for the human - a 6 protein in the Fluorescence Polarisation Assay for GSK 30083...

YN370056 Esaxerenone 1632006-28-0

Esaxerenone is a novel, highly potent and selective non-steroidalmineralocorticoid receptorantagonist.

YN320123 BAR501 1632118-69-4

BAR501 is a potent and selective agonist ofGPBAR1with an EC50 of 1μM.

YN370887 PF-06446846 hydrochloride 1632250-50-0

PF-06446846 hydrochloride is an orally active and highly selective inhibitor oftranslation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall ...

YN300014 Mavacamten 1642288-47-8

Mavacamten (MYK-461) is a small-molecule modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy (HCM), one of the most prevalent heritable cardiovascular disorders.

YN310013 GSK484 hydrochloride 1652591-81-5

GSK484 HCl, a benzoimidazole derivative, is a selective and reversible inhibitor of peptidylarginine deiminase 4 (PAD4) with IC50 of 50 nM in the absence of Calcium.

YN310106 EML 425 1675821-32-5

EML425 is a potent and selective CREB binding protein (CBP)/p300inhibitor with IC50s of 2.9 and 1.1μM, respectively.

YN481279 NHS-PEG1-SS-PEG1-N... 1688598-83-5

NHS-PEG1-SS-PEG1-NHS is a reversiblelinkerfor biomacromolecule link with active small molecule. NHS-PEG1-SS-PEG1-NHS can be used in proteins liposomes or nanoparticles.