YN480382 SB-633825 956613-01-7

SB-633825 is a potent and ATP-competitive inhibitor ofTIE2,LOK (STK10) and BRKwith IC50s of 3.5nM, 66nM, 150nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis.

YN480117 NIH-12848 959551-10-1

NIH-12848 is a specific PI5P4Kγ inhibitor with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM.

YN372461 Daprodustat 960539-70-2

Daprodustat (GSK1278863) is an orally administered hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor. Phase 2.

YN370139 Vadadustat 1000025-07-9

Vadadustat is a novel, titratable, oral HIF-PH inhibitor.

YN290071 BMS-687453 1000998-59-3

BMS-687453 is a potent and selectivePPARαagonist, with anEC50 and IC50 of 10nM and 260nM for humanPPARα and 4100nM and >15000nM for PPARγ in PPAR-GAL4 transactivation assays.

YN483197 Notoginsenoside FP2 1004988-75-3

Notoginsenoside FP2, a dammarane-Type Bisdesmoside isolated from the Fruit Pedicels ofPanax notoginseng, has potential to treat cardiovascular disease.

YN440116 Vorolanib 1013920-15-4

Vorolanib is an oral, multikinase, dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with antiangiogenic and antineoplastic activities.

YN372642 VTP-27999 TFA 1013937-63-7

VTP-27999 is an orally efficacious, selecitive alkyl amine renin inhibitor with IC50 of 0.47 nM for 0.3 nM of purified recombinant human renin.

YN360547 S0859 1019331-10-2

S0859 is a selective, high-affinity genericNBCinhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (Ki=1.7μM, full inhibition at approximately 30μM).

YN370264 ARL67156 trisodium salt 1021868-83-6

ARL67156 trisodium salt is an inhibitor ofecto-ATPase. ARL 67156 trisodium salt is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively. ARL67156 tri...

YN360281 ATP synthase inhibitor 1 1023043-30-2

ATP synthase inhibitor 1 is a potent inhibitor ofc subunit of the F1/FO-ATP synthasecomplex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels.

YN360700 RN-1747 1024448-59-6

RN-1747 is a selectivetransient receptor potential cation channel subfamily V member 4 (TRPV4)agonist, withEC50values are 0.77μM, 4.0μM and 4.1μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also anta...

YN440105 GSK-626616 1025821-33-3

GSK-626616 is a potent, orally bioavailable inhibitor ofDYRK3(IC50=0.7nM). GSK-626616 inhibits other members of the DYRK family (e.g., DYRK1A and DYRK2) with similar potency, which is a potential therapy for the ...

YN321158 Losartan D4 1030937-27-9

Losartan D4 (DuP-753 D4) is the deuterium labeled Losartan. Losartan is anangiotensin II receptorantagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20nM.

YN330010 TPO agonist 1 1033040-23-1

TPO agonist 1 is athrombopoietin (TPO)agonist extracted from patent WO2008134338A1, compound TPO mimetic. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia.

YN320468 AZD2906 1034148-15-6

AZD2906 is a selectiveglucocorticoid receptor (GR)agonist, increases micronucleated immature erythrocytes in the bone marrow of rats. AZD2906 shows IC50s of 2.2, 0.3, 41.6 and 7.5nM at GR in human, rat PBMC and human, r...

YN372353 LP-533401 hydrochloride 1040526-12-2

LP-533401 hydrochloride is atryptophan hydroxylase 1inhibitor that regulates serotonin production in the gut.

YN450056 Cardiogenol C hydrochloride 1049741-55-0

Cardiogenol C hydrochloride is a potent cell-permeable pyrimidine inducer which prompts thedifferentiation of ESCs into cardiomyocytes(EC50=100nM). Cardiogenol C hydrochloride also acts cardiomyogenic on already lineage-committed ...

YN370505 Finerenone 1050477-31-0

Finerenone (BAY 94-8862) is a third-generation, selective,  and  orally available nonsteroidalmineralocorticoid receptor (MR)antagonist (IC50=18nM). Finerenone displays excellent selectivity versus glucocorticoid rece...

YN360324 VU0134992 hydrochloride 1052515-91-9

VU0134992 hydrochloride is the first subtype-preferring, orally active and selectiveKir4.1 potassium channelpore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1...