YN321089 Ralinepag 1187856-49-0

Ralinepag is a potent, orally bioavailable and non-prostanoidprostacyclin (IP) receptoragonist, with EC50s of 8.5nM, 530nM and 850nM for human and rat IP receptor and human DP1 receptor, respectively.

YN360760 Nifedipine D6 1188266-14-9

Nifedipine D6 (BAY-a-1040 D6) is deuterium labeled nifedipine, and nifedipine is a potent calcium channel blocker.

YN360750 Dofetilide D4 1189700-56-8

Dofetilide D4 (UK 68789 D4) is a deuterium labeled Dofetilide. Dofetilide is a class III antiarrhythmic agent.

YN372858 Acetazolamide D3 1189904-01-5

Acetazolamide D3 is deuterium labeled Acetazolamide, which is a potent carbonic anhydrase (CA) inhibitor.

YN372325 Bivalirudin TFA 1191386-55-6

Bivalirudin TFA is a synthetic 20 residue peptide which reversibly inhibits thrombin.

YN321252 Burixafor hydrobromide 1191450-19-7

Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent antagonist ofCXCR4 and a well water soluble anti-angiogenic drug that is of potential value in treating choroid neovascularization. Burixafor hydr...

YN370255 HSF1A 1196723-93-9

HSF1A is a cell-permeable heat shock transcription factor 1 (HSF1) activator. HSF1A protects cells from stress-induced apoptosis, binds TRiC subunits and inhibits TRiC activity without perturbation of ATP hydrolysis.

YN360648 BI-9627 1204329-34-9

BI-9627 is asodium-hydrogen exchanger isoform 1 (NHE1)inhibitor with an EC50 of 31nM.

YN370814 H-Ile-Pro-Pro-OH hydroch... 1208862-61-6

H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide , inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5μM. Antihypertensive tripeptides.

YN480904 5-Hydroxy Propafenone D5 H... 1215370-87-8

5-Hydroxy Propafenone D5 Hydrochloride is the deuterium labeled 5-Hydroxy Propafenone.

YN320938 SCH79797 dihydrochloride 1216720-69-2

SCH79797 dihydrochloride is a highly potent, selective nonpeptideprotease activated receptor 1 (PAR1)antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide toPAR1with an IC...

YN360625 Bumetanide D5 1216739-35-3

Bumetanide D5 is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl-(NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0μM for hNKCC1A and hNKCC2A, respectively.

YN321425 Irbesartan D4 1216883-23-6

Irbesartan D4 is the deuterium labeled Irbesartan, which is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist.

YN360819 (R)-Lercanidipine D3 hydroc... 1217724-52-1

(R)-lercanidipine D3 (hydrochloride) is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine D3 (hydrochloride), the R-enantiomer of Lercanidipine, is acalcium channelblocker.

YN481839 (S)-Lercanidipine D3 hydroc... 1217740-02-7

(S)-Lercanidipine D3 (hydrochloride) is a deuterium labeled Lercanidipine D3 hydrochloride. (S)-Lercanidipine hydrochloride is an antihypertensive agent.

YN370966 Setanaxib 1218942-37-0

GKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectivelyl ~10-fold selectivity towards NOX1, 4 and 5 over NOX2, does not inhibit XO or scavange ROS/RNS.

YN330134 RO2959 hydrochloride 1219927-22-6

RO2959 hydrochloride is a potent and selectiveCRAC channelinhibitor with an IC50 of 402nM. RO2959 hydrochloride is a potent blocker ofstore operated calcium entry (SOCE)mediated byOrai1/Stim1 channelswith an IC50 of 25n...

YN372549 XL-784 1224964-36-6

XL-784 is a selectivematrix metalloproteinases (MMP)inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56nM for MMP-1，MMP-2，MMP-3，MMP-8，MMP-9，MMP-13，respectively.

YN370246 Edoxaban tosylate monohydrate 1229194-11-9

Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.

YN360349 DSP-2230 1233231-30-5

DSP-2230 is a selectiveNav1.7/Nav1.8blocker.