YN250027 Aprepitant 170729-80-3

Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM.

YN480049 Substituted piperidines-1 170842-46-3

Substituted piperidines-1 is a compound that can promote the release of growth hormone in humans and animals.

YN320029 AGN 192836 171102-29-7

AGN 192836 is a potent and selectiveα2 adrenergicagonist with EC50s of 8.7, 41 and 6.6nM for α2A, α2B and α2C receptor, respectively.

YN321894 Urocortin, rat 171543-83-2

Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenousCRFRagonist with Kis of 13nM, 1.5nM, and 0.97nM forhuman CRF1,rat CRF2α and mouse CRF2β, respectively.

YN320976 Darusentan 171714-84-4

Darusentan (Lu-135252) is a selectiveendothelin receptor A(ET-A)receptorantagonist, which binds with a Ki of 1.4nM to the ET-A receptor and a Kiof 184nM to ET-B receptor, respectively with a 100-fold selectivity for ETA...

YN322025 YM-46303 171722-81-9

YM-46303 is anmAChRantagonist which exhibits the highest affinities for M1 and M3 receptors, and selectivity for M3 over M2 receptor.

YN321661 Acrivastine D7 172165-56-9

Acrivastine D7 (BW825C D7) is a deuterium labeled Acrivastine. Acrivastine is a short acting histamine 1 receptor antagonist.

YN320862 Fosaprepitant 172673-20-0

Fosaprepitant (L785298) is a prodrug of Aprepitant (HY-10052). Fosaprepitant is aneurokinin-1 receptorantagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting.

YN321047 BQ-788 173326-37-9

BQ-788 is a potent, selectiveETB receptorantagonist with IC50 of 1.2nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC c...

YN320974 Atrasentan 173937-91-2

Atrasentan (ABT-627) is anendothelin receptorantagonist with IC50 of 0.0551nM for ETA.

YN481229 Raloxifene 6-glucuronide 174264-50-7

Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds toestrogen receptor with an IC50 of 290μM. Raloxifene is a s...

YN321022 SB-222200 174635-69-9

SB-222200 is a potent, selective, orally active and blood-brain barrier (BBB) penetrantNK-3 receptorantagonist. SB-222200 is developed for central nervous system (CNS) disorders.

YN320885 Talnetant 174636-32-9

Talnetant (SB 223412) is a potent and selective NK3 receptor antagonist (ki=1.4nM, hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM. in vit...

YN320819 CP 316311 175139-41-0

CP 316311 is a potent and selectiveCRF1 receptorantagonist with an IC50 value of 6.8nM.

YN320820 CP 376395 175140-00-8

CP 376395 is a potent  and  selectiveCorticotropin releasing factor 1 (CRF1)receptor antagonist.

YN321893 Urocortin, human 176591-49-4

Urocortin, human, a 40-aa neuropeptide, acts as a selective agonist of endogenousCRF2receptor, with Kis of 0.4, 0.3, and 0.5nM for hCRF1, rCRF2α and mCRF2β, respectively.

YN320706 Ambrisentan 177036-94-1

Ambrisentan is a highly selective antagonist of the endothelin-1 type A receptor, used in the treatment of pulmonary arterial hypertension (PAH).

YN321172 NKP608 177707-12-9

NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6nM) and in vivo. In vitro, the binding of NKP608 t...

YN481233 LY88074 177744-96-6

LY88074 (Compound 88074) is a Raloxifene analog lacking the basic side chain. Raloxifene is a selective estrogen receptor modulator, and reduces fracture risk at least in part by improving the mechanical properties of bone in a cell-...

YN320157 PD-159020 177904-00-6

PD-159020 is a non-selectiveETA/ETBantagonist, with IC50s of 30 and 50nM for hETA and hETB, respectively.