YN322083 Tachykinin angatonist 1 178310-77-5

Tachykinin angatonist 1 is aneurokinin receptorantagonist extracted from patent US5968923, compound example 32.

YN322068 YM158 free base 179102-65-9

YM158 free base is a potent and selectiveLTD4 and TXA2receptorantagonist withpA2values of about 8.87 and 8.81, respectively.

YN321958 Pancreatic Polypeptide, bovi... 179986-89-1

Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion; Pancreatic Polypeptide, bovine acts as an agonist...

YN321118 Tezosentan 180384-57-0

Tezosentan (RO 610612) is anendothelin (ET)receptor antagonist, withpA2sof 9.5, 7.7 for ETA and ETBreceptors, respectively.

YN321083 SB225002 182498-32-4

SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.

YN481230 Raloxifene 4'-glucuronide 182507-22-8

Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds toestrogen receptor with an IC50 of 370μM.. Ra...

YN481240 LY88074 analog 1 183060-99-3

LY88074 analog 1 is abenzothiophene compoundwith nitrogen-containing non-basic side chains, Compound 26, extracted from patent EP0747380A1. LY88074 analog 1 is an agent for alleviating the symptoms of post-menopausal symptoms, such ...

YN321858 Guanylin(human) 183200-12-6

Guanylin(human), a 15-amino acid peptide, is an endogenousintestinal guanylate cyclaseactivator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia t...

YN320753 Abarelix 183552-38-7

Abarelix (R3827; PPI 149) is a potentgonadotrophin-releasing hormone (GnRH)antagonist, used for prostate cancer treatment.

YN321865 CYN 154806 183658-72-2

CYN 154806, a cyclic octapeptide, is a potent and selectivesomatostatin sst2 receptorantagonist, withpIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.

YN320893 Ciproxifan 184025-18-1

Ciproxifan (FUB 359) is a potent, selective, orally bioavailable and competitive antagonist ofhistamine H3-receptor, with an IC50 of 9.2nM. Ciproxifan displays low apparent affinity at other receptor subtypes. Ciproxifan can be ...

YN320960 Ciproxifan maleate 184025-19-2

Ciproxifan is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.

YN321306 Sitaxsentan 184036-34-8

Sitaxsentan (IPI 1040; TBC-11251) is a selective endothelin A (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is used in treatment of chronic heart failure.

YN321050 AMD 3465 hexahydrobromide 185991-07-5

AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist ofCXCR4, inhibits binding of 12G5 mAb and CXCL12AF647toCXCR4, with IC50s of 0.75nM and 18nM in SupT1 cells; AMD 3465 also po...

YN321051 AMD 3465 185991-24-6

AMD 3465 (GENZ-644494) is a potent antagonist ofCXCR4, inhibits binding of 12G5 mAb and CXCL12AF647toCXCR4, with IC50s of 0.75nM and 18nM in SupT1 cells; AMD 3465 also potently inhibits the replication of...

YN370940 MSI-1436 186139-09-3

MSI-1436 is a selective, non-competitive inhibitor of the enzymeprotein-tyrosine phosphatase 1B (PTB1B), with an IC50 of appr 1μM, 200-fold preference over TCPTP (IC50, 224μM).

YN320536 BMS-193885 186185-03-5

BMS-193885 is a potent, selective, competitive, and brain penetrantneuropeptide Y1receptorantagonist with a Ki of 3.3nM, and has an IC50 of 5.9nM for hY1, which displays > 100, > 160, > 160 and > 160-fold selectivity over α...

YN320085 Zibotentan 186497-07-4

Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.

YN321212 ZD-1611 186497-38-1

ZD-1611 is a potent, orally active, selectiveETA receptorantagonist, used for the research of ischemic stroke.

YN330596 Ginsenoside Rg5 186763-78-0

Ginsenoside Rg5 is the main component of Red ginseng. Ginsenoside blocks binding ofIGF-1to its receptor with an IC50 of ~90nM. Ginsenoside Rg5 also inhibits the mRNA expression ofCOX-2via suppression of the DNA binding ...