YN321987 Cortistatin-14 186901-48-4

Cortistatin-14, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 shows anticonvulsive, neuroprotective effect and remarkable anti-in...

YN440326 KU14R 189224-48-4

KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.

YN320140 L-765314 189349-50-6

L-765314 is a potent and selectiveα1b adrenergic receptorantagonist with Kis of 5.4nM and 2.0nM for rat and human α1b adrenergic receptor, respectively.

YN321326 Bepotastine besilate 190786-44-8

Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.

YN481747 Lasofoxifene Tartrate 190791-29-8

Lasofoxifene Tartrate is a third-generation, non-steroidal selective estrogen receptor modulator (SERM) which binds with high affinity to the human estrogen receptor-α with IC50 value of 1.5 nM.

YN322074 5-HT2 antagonist 1 191592-09-3

5-HT2 antagonist 1 is a potent antagonist of5-HT2 receptor, with weakα1 adrenoceptorblocking activity.

YN321234 CS-003 Free base 191672-52-3

CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with Ki values of 2.3nM, 0.54nM and 0.74nM, respectively. CS-003 Free base (C...

YN320335 CGP71683 hydrochloride 192322-50-2

CGP71683 hydrochloride is a competitiveneuropeptide Y5 receptorantagonist with a Ki of 1.3nM, and shows no obvious activity at Y1 receptor (Ki, >4000nM) and Y2 receptor (Ki, 200nM) in cell membranes.

YN320949 Capromorelin Tartrate 193273-69-7

Capromorelin Tartrate (CP 424391-18), a member of the growth hormone secretagogue (GHS) class of drugs, is a ghrelin receptor agonist and a novel therapy for stimulation of appetite in dogs with Ki of 7 nM for hGHS...

YN320818 R121919 195055-03-9

R121919 (NBI30775) is a potent small-moleculeCRF1receptor antagonist with a Ki of 2 to 5nM for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types.

YN320532 A-192621 195529-54-5

A-192621 is a potent, nonpeptide, orally active and selectiveendothelin B (ETB) receptorantagonist with an IC50 of 4.5nM and a Ki of 8.8nM. The selectivity of A-192621 is 636-fold higher than ETA(IC50 of 4280nM and K...

YN320975 Atrasentan hydrochloride 195733-43-8

Atrasentan hydrochloride (ABT-627 hydrochloride) is a selectiveendothelin A receptorantagonist with an IC50 of 0.0551nM for ETA.

YN321325 Ramelteon 196597-26-9

Ramelteon is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively.

YN480706 Asoprisnil 199396-76-4

Asoprisnil (J867), a selectiveprogesterone receptormodulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human.

YN322049 L-771688 200050-59-5

L-771688 is a highly selectiveα1A-Adrenoceptorantagonist with a Ki of 0.43±0.02nM.

YN320871 Bilastine 202189-78-4

Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine and has a rapid onset and prolonged duration of action.

YN480740 DMP 696 202578-52-7

DMP 696 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist, used for the treatment of anxiety and depression.

YN321927 Orexin B, rat, mouse 202801-92-1

Orexin B, rat, mouse is an endogenous agonist atOrexinreceptor with Kis of 420 and 36nM for OX1 and OX2, respectively.

YN320886 Talnetant hydrochloride 204519-66-4

Talnetant Hcl(SB 223412 Hcl) is a potent and selective NK3 receptor antagonist(ki=1.4nM, hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM...

YN320792 LY377604 204592-94-9

LY377604 is ahuman β3-adrenergic receptoragonist with an EC50 of 2.4nM and also aβ1- and β2-adrenergic receptorantagonist.