YN321220 WAY-151932 220460-92-4

WAY-151932 is avasopressin V2-receptoragonist with IC50 of 80.3nM and 778nM in human-V2binding and V1abinding assay.

YN320388 RO1138452 221529-58-4

RO1138452 is a potent and selectiveIP(prostacyclin)receptorantagonist. RO1138452 displays high affinity for IP receptors. In human platelets,pKiis 9.3±0.1; in a recombinant IP receptor system,pKiis 8.7±0.06.

YN320424 SR 146131 221671-61-0

SR 146131 is a potent, orally available, and selective nonpeptide (cholecystokinin 1) receptor agonist.

YN320183 Y1 receptor antagonist 1 221697-09-2

Y1 receptor antagonist 1 (H 409-22 isomer) is aneuropeptide Y1 receptorantagonist.

YN322075 (4E)-SUN9221 222318-55-0

(4E)-SUN9221 is a potent antagonist ofα1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.

YN320918 Evatanepag 223488-57-1

Evatanepag (CP-533536) is an EP2 receptor selective prostagl and in E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3nM.in vitro: CP-533536 is a potent and selective EP2agonist. CP-533536 demonstrates ...

YN320908 Mirabegron 223673-61-8

Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.

YN372801 Vardenafil 224785-90-4

Vardenafil is a selective, orally active, potent inhibitor ofphosphodiesterase-5 (PDE5), with an IC50 of 0.7nM. Vardenafil shows selectivity over PDE1 (180nM), PDE6 (11nM), PDE2, PDE3, and PDE4 (>1000nM). Varde...

YN322077 AR-08 226081-74-9

AR-​08 is an agonist ofα2-adrenergic receptor, used for the treatment of attention deficit hyperactivety disorder (ADHD).

YN320731 TAK-779 229005-80-5

TAK-779 is a potent and selective nonpeptide antagonist ofCCR5 and CXCR3, with a Ki of 1.1nM for CCR5, and effectively and selectively inhibitsR5 HIV-1, withEC50 and EC90of 1.2nM and 5.7nM, respectively, in ...

YN320211 BIIE-0246 246146-55-4

BIIE-0246 is a potent and highly selectivenon-peptide neuropeptide Y (NPY) Y2receptor antagonist, with an IC50 of 15nM.

YN321577 Fimasartan 247257-48-3

Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure.

YN320389 SB-334867 249889-64-3

SB-334867 (SB 334867A) is an excellent,selective and blood–brain barrier permeableorexin-1 (OX1) receptorantagonist, shows selectivity overOX2(pKb=7.4), 100-fold over 5-HT2B, 5-HT2Cwith pKi values. of 5.4 and 5.3, resp...

YN320901 Anamorelin 249921-19-5

Anamorelin (ONO-7643, RC-1291, ST-1291) is an orally active, high-affinity, selective agonist of the ghrelin receptor with an EC50 value of 0.74 nM in the HEK293/GRLN FLIPR assay.

YN321223 Solabegron 252920-94-8

Solabegron (GW 427353) is a selectiveβ3-adrenergic receptoragonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22nM. Solabegron (GW 427353) is being develo...

YN321170 Sparsentan 254740-64-2

Sparsentan is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.

YN321018 AL 082D06 256925-03-8

AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.

YN370909 Torcetrapib 262352-17-0

Torcetrapib is a CETP inhibitor with IC50 of 37 nM, elevates HDL-C and reduces nonHDL-C in plasma. Phase 3.

YN320863 Fosaprepitant dimeglumine 265121-04-8

Fosaprepitant is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.

YN320950 Reparixin 266359-83-5

Reparixin(Repertaxin) is a inhibitor of human CXCR1/R2 and rat CXCR2 receptor activation. It also inhibits human CXCL8 receptor activation.