YN321259 TAK-220 333994-00-6

TAK-220 is a selective and orally bioavailableCCR5antagonist, with IC50s of 3.5nM and 1.4nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively, but shows no effect on the binding to CCR1...

YN320867 Velneperit 342577-38-2

Velneperit (S-2367) is a novel neuropeptide Y (NPY) Y5 receptor antagonist.

YN320069 Cetirizine Impurity D 346451-15-8

Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamineH1-receptorantagonist. Cetirizine marks antiallergic properties and inhibits...

YN480268 Eprotirome 355129-15-6

Eprotirome (KB2115) is a liver-selective agonist of thyroid hormone receptor (TR). Eprotirome is investigated for the potential treatment of dyslipidemias and obesity.

YN321984 Urocortin III, mouse 357952-10-4

Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activatesCRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system...

YN480701 3-Keto petromyzonol 359436-56-9

3-Keto petromyzonol, a main component of Sea lamprey male sex pheromones, modulates both synthesis and release of gonadotropin releasing hormone (GnRH), and subsequently, hypothalamic-pituitary-gonadal (HPG) output in immature s...

YN320560 Pitolisant 362665-56-3

Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant humanhistamine H3 receptor(Ki=0.16nM).

YN320561 Pitolisant oxalate 362665-57-4

Pitolisant oxalate is a potent and selective nonimidazole inverse agonist at the recombinant humanhistamine H3 receptor(Ki=0.16nM).

YN320047 TCS-OX2-29 372523-75-6

TCX-OX2-29 is a OX2R antagonist (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively).

YN484239 KAT681 373641-87-3

KAT681 is a liver-selective thyromimetic.

YN321838 Kisspeptin-54(human) 374683-24-6

Kisspeptin-54(human) (Metastin(human)) is an endogenous lig and forkisspeptin receptor (KISS1, GPR54). Kisspeptin-54(human) binds torat and human GPR54 receptorswith Ki values of 1.81nM and 1.45nM, respectively. Kisspept...

YN320679 Maraviroc 376348-65-1

Maraviroc is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively.

YN320353 SB-649868 380899-24-1

SB-649868 is a potent and selective orally activeorexin(OX)1 and OX2receptor antagonist (pKi=9.4 and 9.5 at the OX1 and OX2receptor, respectively).

YN320032 SB-568849 395679-53-5

SB-568849 is amelanin-concentrating hormone receptor 1(MCH R1) antagonist with a pKi of 7.7.

YN321313 Pasireotide L-aspartate salt 396091-77-3

Pasireotide(SOM 230) is a stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9 respectively). IC50 value: 8.2/9.0/9.1/<...

YN320558 JNJ-5207852 398473-34-2

JNJ-5207852 is a selective and potenthistamine H3receptor (H3R) antagonist, withpKisof 8.9, 9.24 for rat and human H3R, respectively.

YN370399 Lodenafil carbonate 398507-55-6

Lodenafil carbonate, a dimer that acts as a prodrug delivering Lodenafil in vivo, is an orally activephosphodiesterase type 5 (PDE5)inhibitor for the treatment of erectile dysfunction (ED).

YN321287 ONO-AE3-208 402473-54-5

ONO-AE3-208 is anEP4antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer.

YN320314 GW 766994 408303-43-5

GW 766994 (GW 994) is an orally active and specificchemokine receptor-3 (CCR3)antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research.

YN321095 Grapiprant 415903-37-6

Grapiprant (CJ-023423) is a selectiveEP4 receptorantagonist whose physiological lig and is prostagl and in E2(PGE2). Grapiprant displaces [3H]-PGE2(1nM) binding to dog recombinantEP4 receptor with IC50 value of 35nM an...