Chemical structure
Cat.No.
Product Name
CAS no.
Target
YN440103 GSK1904529A 1089283-49-7
GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM in cell-free assays, >100-fold more selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc.
YN320148 IT1t dihydrochloride 1092776-63-0
IT1t dihydrochloride is a potentCXCR4antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1nM.
YN320474 BI-671800 1093108-50-9
BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and...
YN320872 JNJ-31020028 1094873-14-9
JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors.
CCX140 (CCX140-B) is a potentCCR2antagonist.
YN321048 Aprocitentan 1103522-45-7
Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dualETA/ETBantagonist with IC50s of 3.4nM and 987nM, and pA2valus of 6.7 a...
YN320925 Bavisant dihydrochloride hydr... 1103522-80-0
Bavisant dihydrochloride hydrate (JNJ31001074AAC) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for A...
MK-4256 is a potent and selectiveSSTR3antagonist with IC50s of 0.66nM and 0.36nM in human and mouse receptor binding assays, respectively.
YN320419 SNT-207858 free base 1104662-66-9
SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally activemelanocortin-4(MC-4)receptorantagonist. SNT207858 free base has an IC50 of 22nM (binding) and 11nM (function) on the MC-4 recepto...
YN440240 GSK1838705A 1116235-97-2
GSK1838705A is a potent IGF-1R inhibitor with IC50 of 2.0 nM, modestly potent to IR and ALK with IC50 of 1.6 nM and 0.5 nM, respectively, and little activity to other protein kinases.
YN321388 Doxazosin D8 1126848-44-9
Doxazosin D8 (UK 33274 D8) is a deuterium labeled Doxazosin (UK 33274). Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1 adrenergic receptors.
BRD7552, a potentPDX1transcription factor inducer, upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. B...
YN320380 TM-N1324 1144477-35-9
TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9nM/5nM in the presence of Zn2+, and 280nM/180nM in the absence of Zn2+forhuman/murine GPR39.
YN481784 Methimazole D3 1160932-07-9
Methimazole D3 is a deuterium labeled Methimazole. Methimazole is an antithyroid drug used for the treatment of the hyperthyroidism in humans and animals.
TG4-155 is a potent, brain-permeant and selectiveEP2 receptorantagonist with a Ki of 9.9nM. TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1. TG4-155 has an EP2 Schild KBof 2.4nM and display...
ML 145 is a selectiveGPR35/CXCR8antagonist with anIC50/EC50of 20.1nM, but not for the related GPR55 orphan receptor. GPR35 is expressed by various cells of the immune system and it may has potential as a therapeutic ta...
YN481378 Ligandrol 1165910-22-4
Ligandrol (LGD-4033, VK-5211) is a novel nonsteroidal, oral selective androgen receptor modulator with high affinity (Ki of ∼1 nM) and selectivity.
YN321341 Doxylamine D5 1173020-59-1
Doxylamine D5 is deuterium labeled Doxylamine.
YN320074 Clenproperol-D7 1173021-09-4
Clenproperol-D7 is the deuterium labeled Clenproperol. Clenproperol is a β2-adrenergic agonist.
YN321188 RS102895 hydrochloride 1173022-16-6
RS102895 hydrochloride is a potentCCR2antagonist, with an IC50 of 360nM, and shows no effect on CCR1.
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