YN321342 Doxylamine D5 succinate 1216840-94-6

Doxylamine D5 succinate is deuterium labeled Doxylamine, which is a first generation antihistamine.

YN321425 Irbesartan D4 1216883-23-6

Irbesartan D4 is the deuterium labeled Irbesartan, which is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist.

YN320678 TSHR antagonist S37 1217616-61-9

TSHR antagonist S37 is a selective and competitivethyrotropin receptor (TSHR)antagonist. TSHR antagonist S37 is the racemate of TSHR antagonist S37a.

YN321401 Ivabradine D3 Hydrochloride 1217809-61-4

Ivabradine D3 Hydrochloride is the deuterium labeled Ivabradine hydrochloride. Ivabradine hydrochloride is a new Ifinhibitor with IC50 of 2.9μM, and used as a pure heart rate lowering agent.

YN321039 MK-7246 1218918-62-7

MK-7246 is a potent and selectiveCRTH2antagonist with a Ki of 2.5±0.5nM.

YN320571 MK-3697 1224846-01-8

MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95nM.

YN320396 Balovaptan 1228088-30-9

Balovaptan (RG7314) is a highly potent and selective brain-penetrantvasopressin 1a (hV1a) receptorantagonist, with Kis of 1 and 39nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.

YN320016 GSK2239633A 1240516-71-5

GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with apIC50 of 7.96 ± 0.11.

YN322067 H3 receptor-MO-1 1240914-03-7

H3 receptor-MO-1 is a modulator ofhistamine H3 receptor.

YN320838 Glucocorticoid receptor agoni... 1245526-82-2

Glucocorticoid receptor agonist is a potent Glucocorticoid receptor agonist.

YN320642 Losartan (D4 Carboxylic Ac... 1246820-62-1

Losartan D4 Carboxylic Acid (E-3174 D4) is the deuterium labeled Losartan(EXP-3174), which is an angiotensin II receptor antagonist.

YN321499 Sotalol D6 hydrochloride 1246820-85-8

Sotalol D6 hydrochloride is a deuterium labeled Sotalol hydrochloride. Sotalol hydrochloride is a non-selective competitiveβ-adrenergic receptorantagonist that also exhibits Class III antiarrhythmic properties by its inhibition ofp...

YN320476 SSTR5 antagonist 2 TFA 1254733-98-6

SSTR5 Antagonist 1 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5)antagonist and has potential to treat type 2 diabetes mellitus (T2DM).

YN320249 JP1302 dihydrochloride 1259314-65-2

JP1302 dihydrochloride is a selective, high affinity antagonist of thealpha2C-adrenoceptor (α2C-adrenoceptor), with aKbvalue (antagonist activity) of 16nM and a Ki(binding affinity) value of 28nM.

YN321281 INCB3344 1262238-11-8

INCB3344 is a potent, selective and orally bioavailableCCR2antagonist with IC50 values of 5.1nM (hCCR2) and 9.5nM (mCCR2) in binding antagonism and 3.8nM (hCCR2) and 7.8nM (mCCR2) in antagonism of chemotaxis...

YN370907 APX-115 free base 1270084-92-8

APX-115 free base (Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-182...

YN320407 BMS-813160 1286279-29-5

BMS-813160 is a potent, well-absorbed dual CCR2 and CCR5 chemokine antagonist. BMS-813160 inhibits inflammatory processes, angiogenesis, tumor cell migration, tumor cell proliferation and invasion.

YN320393 Seltorexant 1293281-49-8

Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selectiveorexin-2 receptor (OX2R)antagonist (pKivalues of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrie...

YN320394 Seltorexant hydrochloride 1293284-49-7

Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selectiveOX2Rantagonist (pKivalues of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain ba...

YN320535 CCR1 antagonist 8 1295298-26-8

CCR1 antagonist 8 (compound 19n), a third azaindazole series compound, is aCCR1antagonist, with an IC50 of 1.8nM in Ca2+flux assay.