YN340001 NT157 1384426-12-3

NT157, a selective inhibitor of IRS-1/2(insulin receptor substrate), has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival.

YN320631 Piribedil D8 1398044-45-5

Piribedil D8 (ET-495 D8) is the deuterium labeled Piribedil, which is an antiparkinsonian agent.

YN321097 TG6-10-1 1415716-58-3

TG6-10-1 is anEP2antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors.

YN480329 E6130 1427058-33-0

E6130 is an orally active and highly selectiveCX3CR1modulator, that may be effective for treatment of inflammatory bowel disease.

YN321070 ML314 1448895-09-7

ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9μM); showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization.

YN320398 Relacorilant 1496510-51-0

Relacorilant is a potent, selective and orally bioavailableglucocorticoid receptorantagonist, with a Ki of 7.2nM in HepG2 TAT assay, and also showsKis of 12, 81.2, 210nM for rat, human and monkey glucocorticoid receptor in c...

YN321254 Setmelanotide acetate 1504602-49-6

Setmelanotide acetate (RM-493 acetate) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27nM and 0.28nM for human and rat MC4R, respectively.

YN320401 Nemorexant 1505484-82-1

Nemorexant (ACT-541468) is a potentorexin receptorantagonist extracted from patent WO2015083094A1, compound example 7, hasIC50s of 2nM  and  3nM forOx1receptor and Ox2receptor, respectively.

YN320655 LML134 1542135-76-1

LML134 (compound 18b) is an orally active and high selectiveHistamine 3 receptor (H3R)inverse agonist with Kis of 0.3nM and 12nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R...

YN481837 Taltirelin acetate 1549593-23-8

Taltirelin acetate (TA-0910 acetate) is a superagonist atthyrotropin-releasing hormone receptor (TRH-R)with an IC50 of 910nM and EC50of 36nM for stimulating an increase in cytosolic Ca2+concentration (Ca2+release).

YN321193 Bremelanotide Acetate 1607799-13-2

Bremelanotide Acetate (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist atmelanocortin receptorsincluding the MC3R and MC4R for the treatment of sexual dysfunction.

YN480091 PCO371 1613373-33-3

PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.

YN321540 Propranolol D7 hydrochloride 1613439-56-7

Propranolol D7 hydrochloride is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselectiveβ-adrenergic receptor (βAR)antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8n...

YN320223 TC-G-1008 1621175-65-2

TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist withEC50values of 0.4 and 0.8nM for rat and human receptors respectively.

YN320217 SSTR5 antagonist 1 1628741-91-2

SSTR5 antagonist 1 is a potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonist with IC50s of 9.6 and 57nM for hSSTR5 and mSSTR5, respectively. (Compound 25a)

YN321233 Fezolinetant 1629229-37-3

Fezolinetant is an antagonist of theneurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.

YN370134 BI 689648 1633009-87-6

BI 689648 is a novel, highly selectivealdosterone synthaseinhibitor which can inhibit CYP11B1 and CYP11B2with IC50s of 310 and 2.1nM, respectively.

YN320523 SX-682 1648843-04-2

SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity.

YN320461 CCR2 antagonist 1 1683534-96-4

CCR2 antagonist 1 is a high-affinity and long-residence-timeCCR2antagonist, with a Ki of 2.4nM.

YN320099 ZK756326 dihydrochloride 1780259-94-0

ZK756326 dihydrochloride is a nonpeptide chemokine receptor agonist for the CC chemokine receptorCCR8.