YN481665 ORM-15341 1297537-33-7

ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an and rogen-responsive luciferase repor...

YN370941 MSI-1436 lactate 1309370-86-2

MSI-1436 lactate is a selective, non-competitive inhibitor of the enzymeprotein-tyrosine phosphatase 1B(PTB1B), with an IC50 of 1μM, 200-fold preference over TCPTP (IC50 of 224μM).

YN320688 Olodanrigan 1316755-16-4

Olodanrigan (EMA401, PD-126055, (S) PD-126055) is a highly selective, orally active, peripherally restricted antagonist of angiotensin II type 2 receptor (AT2R). Olodanrigan (EMA401) analgesic action appears to involve the...

YN321988 Etelcalcetide hydrochloride 1334237-71-6

Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide as an activator of thecalcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in ...

YN320614 PF-5190457 1334782-79-4

PF-5190457 (PF-05190457) is a potent and selectiveghrelin receptorinverse agonist with a pKi of 8.36.

YN320586 ML224 1338824-21-7

ML224(NCGC00242364; ANTAG3) is a selective TSHR inverse agonist; inhibits TSH-stimulated cAMP production with an IC50 = 2.3μM.

YN320712 PF-4136309 1341224-83-6

PF-4136309 is a potent, selective, and orally bioavailableCCR2antagonist, with IC50s of 5.2nM, 17nM and 13nM for human, mouse and rat CCR2.

YN270005 GSK583 1346547-00-9

GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM.

YN320064 Diacetolol D7 1346604-19-0

Diacetolol D7 is a deuterium labeled Diacetolol. Diacetolol is the major metabolite of Acebutolol. Diacetolol is aβ-adrenoceptorblocking and anti-arrhythmic agent.

YN1580001 Bis-propargyl-PEG9 1351373-47-1

Bis-propargyl-PEG9 is aPEG-based PROTAC linkerused in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor lig and s.

YN440334 AZD-3463 1356962-20-3

AZD3463 is a novel orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency.

YN321878 Atrial Natriuretic Peptide ... 1366000-58-9

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. ANP (1-28) inhibitsend...

YN320229 E7046 1369489-71-3

E7046 is a selective inhibitor of the prostaglandin E_{2 (PGE2) receptor EP4} with IC50 of 13.5 nM and Ki of 23.14 nM.

YN480988 CO23 1370363-74-8

CO23 is a selectivethyroid hormone receptor (TR) αagonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier.

YN320479 USL311 1373268-67-7

USL311 is a selectiveCXCR4antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4.

YN320806 IPSU 1373765-19-5

IPSU is a selective, orally available and brain penetrantOX2Rantagonist with a pKi of 7.85.

YN320452 CRTh2 antagonist 1 1379445-54-1

CRTh2 antagonist 1 is aCRTh2antagonist with an IC50 of 89nM。

YN320120 CCR2 antagonist 3 1380100-86-6

CCR2 antagonist 3 is a chemokine receptor 2(CCR2)antagonist.

YN480791 JMS-17-2 1380392-05-1

JMS-17-2 is a potent and selective small-molecule antagonist of CX3C chemokine receptor 1 (CX3CR1/GPR13) with IC50 of 0.32 nM. JMS-17-2 is used in the research of metastatic disease in breast cancer patients.

YN440336 Ceritinib dihydrochloride 1380575-43-8

Ceritinib (Zykadia, LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK with IC50 of 0.2 nM. Ceritinib dihydrochloride also inhibits InsR, IGF-1R and ...