3-Hydroxy Midostaurin
Cat. No. :YN440110
CAS No. :179237-49-1
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order@ubiochem.com| Product Name: | 3-Hydroxy Midostaurin |
| CAS NO.: | 179237-49-1 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 586.64 |
| Molecular Formula: | C₃₅H₃₀N₄O₅ |
| SMILES: | OC1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(O[C@@H](N7C5=C2C8=C7C=CC=C8)C[C@H]([C@H]6OC)N(C(C9=CC=CC=C9)=O)C)C)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibitsFMS-like tyrosine kinase-3 (FLT3)autophosphorylation with IC50s of approximately 132nM and 9.8μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412. |
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