Crenolanib
Cat. No. :YN440254
CAS No. :670220-88-9
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order@ubiochem.com| Product Name: | Crenolanib |
| CAS NO.: | 670220-88-9 |
| Chemical Name: | |
| Synonyms: | ARO 002 |
| Molecular Weight: | 443.54 |
| Molecular Formula: | C₂₆H₂₉N₅O₂ |
| SMILES: | NC1CCN(C2=CC=CC3=C2N=C(N4C5=CC=C(C=C5N=C4)OCC6(COC6)C)C=C3)CC1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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