YN483832 Ac9-25 284040-76-2

Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR.

YN330408 Salicylic acid-D6 285979-87-5

Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.

YN350026 Doramapimod 285983-48-4

Doramapimod (BIRB 796) is a  pan-p38 MAPK inhibitor with IC50 of  38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ in cell-free assays, and binds p38α with Kd of 0.1 nM in THP-1 cells, 330-fold greater se...

YN410062 (-)-DHMEQ 287194-40-5

(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammat...

YN410063 (+)-DHMEQ 287194-41-6

(+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.

YN330327 Y-320 288250-47-5

Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.

YN320540 BX471 hydrochloride 288262-96-4

BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptideCCR1antagonist with Kiof 1nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.

YN321065 Treprostinil sodium 289480-64-4

Treprostinil sodium (UT-15, Remodulin, Orenitram, Tyvaso, Trevyent) is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively.

YN370333 Arimoclomol 289893-25-0

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via t...

YN370334 Arimoclomol maleate 289893-26-1

Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the...

YN372547 AE-3763 291778-77-3

AE-3763 is a peptide-basedhuman neutrophil elastaseinhibitor with an IC50 of 29nM.

YN370080 Roflumilast N-oxide 292135-78-5

Roflumilast N-oxide is a PDE type 4inhibitor.

YN371532 (Rac)-Mono(3,5,5-trimethylhe... 297182-83-3

(Rac)-Mono(3,5,5-trimethylhexyl) phthalate is a important metabolite of commonly used phthalate plasticizers. (Rac)-Mono(3,5,5-trimethylhexyl) phthalate has immuno-suppressive effect.

YN483929 IRBP (1-20), human 298202-25-2

IRBP (1-20), human contains a major epitope for the H-2bhaplotype. IRBP (1-20), human induces experimental autoimmune uveoretinitis (EAU) in H-2bmice.

YN340097 UC-514321 299420-83-0

UC-514321, a structural analog of NSC370284 with higher activity, directly targetsSTAT3/5 and repressesTET1expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in v...

YN320981 RS 504393 300816-15-3

RS 504393 is a selectiveCCR2chemokine receptor antagonist (IC50 values are 89nM and > 100μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively).

YN370165 SR0987 303126-97-8

SR0987, a SR1078 analog, is aRORγtagonist, with an EC50 of 800nM. SR0987 increases IL17 expression while repressing the expression of PD-1.

YN350041 TAK-715 303162-79-0

TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. Phase 2.

YN420258 SC79 305834-79-1

SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.

YN370037 CL-82198 307002-71-7

CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 i...