YN322098 SEW​2871 256414-75-2

SEW2871 is a highly selective, orally activeS1P1agonist with an EC50 of 13.8nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte num...

YN370133 UK-371804 256477-09-5

UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10nM.

YN330153 CL075 256922-53-9

CL075 (3M002) is a selectiveTLR8agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF...

YN480270 Secoisolariciresinol diglucos... 257930-74-8

Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuro...

YN484035 Uty HY Peptide (246-254) 261172-28-5

Uty HY Peptide (246-254), derived from the ubiquitously transcribed tetratricopeptide repeat gene on the Y chromosome (UTY) protein as an H-Y epitope, H-YDb, is a male-specific transplantation antigen H-Y.

YN361034 CALP2 261969-04-4

CALP2 is acalmodulin (CaM)antagonist ( (Kdof 7.9 µM)) with high affinity for binding to theCaMEF-h and /Ca2+-binding site. CALP2 inhibitsCaM-dependentphosphodiesteraseactivity and increases intracellular Ca2+concentra...

YN380126 Tavilermide 263251-78-1

Tavilermide is a selective, partial agonist ofTrkA, or a nerve growth factor (NGF) mimetic.

YN483416 Rabdosiin 263397-69-9

Rabdosiin is a tetramer of caffeic acid isolated from the stem ofRabdosia japonicaHara. Rabdosiin possess anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.

YN1710006 MRS-1706 264622-53-9

MRS-1706 is a potent and selectiveadenosine A2Breceptorinverse agonist. MRS-1706 hasKivalues of 1.39, 112, 157, and 230nM for human A2B, A2A, A1 and A3receptors respectively.

YN1710027 MRS 1754 264622-58-4

MRS 1754 is a selective antagonist radiolig and forA2Badenosine receptor with very low affinity for A1 and A3receptors of both humans and rats.

YN320950 Reparixin 266359-83-5

Reparixin(Repertaxin) is a inhibitor of human CXCR1/R2 and rat CXCR2 receptor activation. It also inhibits human CXCL8 receptor activation.

YN320951 Reparixin L-lysine salt 266359-93-7

Reparixin L-lysine salt is an allosteric inhibitor ofchemokine receptor 1/2 (CXCR1/2)activation.

YN321910 [Nphe1]Nociceptin(1-13)NH2 267234-08-2

[Nphe1]Nociceptin(1-13)NH2, a novelnociceptin/orphanin FQ (NC)endogenous lig and , is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2 binds selectivel...

YN290551 Myoseverin 267402-71-1

Myoseverina, a microtubule-binding molecule, induces the reversible fission of multinucleated myotubes into mononucleated fragments. Myoseverina affects the expression of a variety of growth factor, immunomodulatory, extracellular matrix-...

YN410136 Coronalolic acid 268214-52-4

Coronalolic acid, extract from the apical bud ofGardenia sootepenesisHutch, inhibits TNF-α-inducedNF-κBactivity and NOproduction.

YN482708 (2S)-2'-Methoxykurarinone 270249-38-2

(2S)-2'-Methoxykurarinone, a compound isolated from the roots ofSophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone...

YN350069 SD 0006 271576-80-8

SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor ofp38α MAP kinase, with an IC50 of 110nM for p38α.

YN270215 Belnacasan 273404-37-8

Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. Phase 2.

YN484053 CCP peptide 277748-59-1

CCP peptide is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide functions as a target for autoantibodies with a very high specificity for rhe...

YN330133 Gamma-glutamylcysteine TFA 283159-88-6

Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcy...