YN322034 Digeranyl bisphosphonate 878143-03-4

Digeranyl bisphosphonate (DGBP) is a potent geranylgeranylpyrophosphate (GGPP) synthase inhibitor, which inhibits geranylgeranylation of Rac1.

YN481103 PA-8 878437-15-1

PA-8 is a potent, selective and orally activePACAP type I (PAC1) receptorantagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP inPAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibi...

YN322065 CCR3 antagonist 1 879399-82-3

CCR3 antagonist 1 is a potent antagonist ofCCR3, used for the research of immunologic and inflammatory diseases.

YN480537 α-2,3-sialyltransferase-IN-... 881179-06-2

α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is a noncompetitiveα-2,3-sialyltransferaseinhibitor with an IC50 of 6μM.

YN300012 Larazotide acetate 881851-50-9

Larazotide acetate is a synthetic peptide. Larazotide acetate acts as a tightjunctionregulator and reverses leaky junctions to their normally closed state.

YN340209 AMG-47a 882663-88-9

AMG-47a is a potent, nonselective inhibitor of Lck kinase with IC50 of 3.4 uM and it also inhibits T cell proliferation. AMG-47a exhibit anti-inflammatory activity (ED50) of 11 mg/kg in the anti-CD3-induced production ...

YN330546 Polygalasaponin F 882664-74-6

Polygalasaponin F, an oleanane-type triterpenoid saponin extracted fromPolygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secret...

YN320742 CCG-50014 883050-24-6

CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.

YN480119 PGD2-IN-1 885066-67-1

PGD2-IN-1 is an antagonist ofDPextracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3nM.

YN321010 GW9508 885101-89-3

GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner.

YN373319 Kongensin A 885315-96-8

Kongensin A is a natural product isolated fromCroton kongensis. Kongensin A is an effective, covalentHSP90inhibitor that blocksRIP3-dependent necroptosishas. Kongensin A is a potentnecroptosisinhibitor and anapoptosisinducer....

YN440385 c-Fms-IN-1 885703-64-0

c-Fms-IN-1 is aFMS kinaseinhibitor with an IC50 of 0.0008μM.

YN321025 Vercirnon sodium 886214-18-2

Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist ofCCR9. Vercirnon sodium inhibits CCR9-mediated Ca2+mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4...

YN320214 Ridaifen-B 886465-70-9

Ridaifen-B (RID-B) is a potent antagonist ofestrogen receptor α (ERα)with IC50 of 52.4nM, a tamoxifen (HY-13757A) derivative. Ridaifen-B is a high affinity, selective, inverse agonist atCB2receptor (Ki=43.7nM) over 17...

YN440312 ZK-261991 886563-25-3

ZK-261991 is an orally activeVEGFRtyrosine kinase inhibitor with an IC50 of 5nM for VEGFR2.

YN481207 O-Methyl Atorvastatin hemic... 887196-29-4

O-Methyl Atorvastatin (hemicalcium) is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids.

YN410044 Mesalamine impurity P 887256-40-8

Mesalamine impurity P is an impurity of Mesalamine (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specificPPARγagonist and also inhibits p21-activated kinase 1 (PAK1) and  NF-κB.

YN310082 OSS_128167 887686-02-4

OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.

YN361054 Transdermal Peptide Disulfi... 888486-23-5

Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) is a 11-amino acid peptide, binds toNa+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus ofATP1B1. Transdermal Peptide Disulfide can e...

YN322084 CB1 antagonist 1 890037-68-0

CB1 antagonist 1 is an antagonist ofCB1 receptor, used in the research of metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, gastrointestinal disorders, and cardiovascular conditions.