YN321069 Setipiprant 866460-33-5

Setipiprant(ACT-129968, KYTH-105) is a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2) that that has been shown to have greater specificity for DP2 (CRTH2) than for DP1.

YN440047 TG 100572 Hydrochloride 867331-64-4

TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibitsreceptor tyrosine kinases and Src kinases; hasIC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PD...

YN320541 Umeclidinium bromide 869113-09-7

Umeclidinium bromide is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).

YN350024 SB 203580 hydrochloride 869185-85-3

SB 203580 hydrochloride (RWJ 64809 hydrochloride) is a selective and ATP-competitivep38 MAPKinhibitor with IC50s of 50nM and 500nM forSAPK2a/p38 and SAPK2b/p38β2, respectively. SB 203580 hydrochloride inhibits...

YN370059 T-26c 869296-13-9

T-26c is a highly potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with IC50 of 6.9 pM, more than 2600-fold selectivity over other related metalloenzymes.

YN321901 Obestatin(rat) 869705-22-6

Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous lig and of G-pr...

YN440136 A-770041 869748-10-7

A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.

YN410125 Andropanolide 869807-57-8

and rographolide ( and ro) is a small antagonist for NF-κB activation by covalent modifying reduced cysteine 62 of p50. and rographolide is a bicyclic diterpenoid lactone mainly produced from the plant and rographis ( and rographis p...

YN360469 A 839977 870061-27-1

A 839977 is aP2X7selective antagonist; it blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20nM, 42nM and 150nM respectively) and reduces inflammatory and neuropath...

YN330288 Apilimod mesylate 870087-36-8

Apilimod mesylate (STA-5326 mesylate) is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod ...

YN440124 GW2580 870483-87-7

GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc.

YN360009 PAP-1 870653-45-5

PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally activeKv1.3blocker (EC50=2nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the ch...

YN350110 Tpl2 Kinase Inhibitor 1 871307-18-5

Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selectiveTpl2(COT kinase,MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers.

YN371023 Resolvin D1 872993-05-0

Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regul...

YN371726 ZAP-180013 873080-25-2

ZAP-180013 is azeta-chain-associated protein kinase 70 (ZAP-70)inhibitor with an IC50 of 1.8μM. ZAP-180013 inhibits the interaction ofZAP-70SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs).

YN410054 IKK 16 873225-46-8

IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively.

YN480272 Rusalatide acetate 875455-82-6

Rusalatide acetate (TP508 amide acetate), a regenerative peptide, mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity.

YN373170 Eupalinolide A 877822-40-7

Eupalinolide A, isolated fromEupatorium lindleyanum, induces the expression of HSP70 via the activation ofHSF1by inhibiting the interaction between HSF1 and HSP90.

YN480062 LOC14 877963-94-5

LOC14 is a potent inhibitor of protein disulfide isomerase (PDI) with EC50 of 500 nM and Kd of 62 nM, respectively.

YN484051 COG1410 878009-24-6

COG1410 is an apolipoprotein E-derived peptide. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease.