YN483313 Epimagnolin B 1134188-26-3

Epimagnolin B is a bisepoxylignan isolated fromMagnolia fargesii, with anti-inflammatory activity and antiallergic effects. Epimagnolin B inhibits NO production in LPS-activated microglia. Epimagnolin B exhibited antiallergic ...

YN371222 MJ33-OH lithium 1135306-36-3

MJ33-OH lithium is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversiblephospholipase A2 (PLA2)inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of P...

YN483230 Ilexhainanoside D 1137648-52-2

Ilexhainanoside D is the main triterpenoid saponin extracted fromIlex hainanensisMerr., and the combination of Ilexhainanoside D and ilexsaponin A1 has anti-inflammation effect.

YN370795 ML604440 1140517-08-3

ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor. ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naïve T helper cells to T helper 17 ...

YN330036 SB290157 trifluoroacetate 1140525-25-2

SB290157 trifluoroacetate is a potent and selectiveC3areceptor antagonist with an IC50 of 200nM.

YN330125 nor-NOHA acetate 1140844-63-8

nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversiblearginaseinhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dy...

YN440120 Edicotinib 1142363-52-7

Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally activecolony-stimulating factor-1 receptor (CSF-1R)inhibitor with an IC50 of 3.2nM. Edicotinib exhibits less inhibitory effects on KIT and FLT...

YN371487 PF-8380 1144035-53-9

PF-8380 is a potent autotaxin inhibitor with IC50 of 2.8 nM in an in vitro enzyme assay.

YN260164 Tr-PEG8-OH 1144113-16-5

Tr-PEG8-OH is a non-cleavable 8 unit PEGADClinker used in the synthesis of antibody-drug conjugates (ADCs).

YN481210 Atorvastatin ethyl ester 1146977-93-6

Atorvastatin ethyl ester is a derivative of Atorvastatin and displays strong inhibition of the 9-cis-RA-induced Gal4 reporter activity.

YN370888 IOX4 1154097-71-8

IOX4 is a potent and selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with IC50 of 1.6 nM. IOX4 induces HIFα in various mouse tissues and human cell lines.

YN410030 Sootepin D 1154518-97-4

Sootepin D (compound 6), a triterpene from the apical bud ofGardenia sootepensis, inhibits TNF-α-inducedNF-κBactivity with an IC50 of 8.3μM. Sootepin D has anti-inflammatory activity.

YN420208 CZC24832 1159824-67-5

CZC24832 is the first selective PI3Kγ inhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3Kβ and >100-fold selectivity over PI3Kα and PI3Kδ.

YN480072 IDE1 1160927-48-9

IDE1 is an inducer of definitive endoderm 1.

YN321201 TG4-155 1164462-05-8

TG4-155 is a potent, brain-permeant and selectiveEP2 receptorantagonist with a Ki of 9.9nM. TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1. TG4-155 has an EP2 Schild KBof 2.4nM and display...

YN480331 ML 145 1164500-72-4

ML 145 is a selectiveGPR35/CXCR8antagonist with anIC50/EC50of 20.1nM, but not for the related GPR55 orphan receptor. GPR35 is expressed by various cells of the immune system and it may has potential as a therapeutic ta...

YN360207 A-967079 1170613-55-4

A-967079 is a selectiveTRPA1receptor antagonist with IC50s of 67nM and 289nM at human and rat TRPA1 receptors, respectively, and has good penetration into the CNS.

YN480729 NS-3-008 hydrochloride 1172854-54-4

NS-3-008 hydrochloride is an orally active transcriptional inhibitor ofG0/G1 switch 2 (G0s2)with an IC50 of 2.25μM. NS-3-008 hydrochloride can be used for chronic kidney disease.

YN321341 Doxylamine D5 1173020-59-1

Doxylamine D5 is deuterium labeled Doxylamine.

YN371607 hDHODH-IN-1 1173715-42-8

hDHODH-IN-1 is ahuman dihydroorotate dehydrogenase (hDHODH)inhibitor. hDHODH-IN-1 has anti-inflammatory effect.