YN320707 AM211 1175526-27-8

AM211 is a potent, selective and orally bioavailableprostagl and in D2 (PGD2) receptor type 2 (DP2)antagonist, with IC50s of 4.9nM, 7.8nM, 4.9nM, 10.4nM for human, mouse, guinea pig, and rat DP2, respectively.

YN483232 Forsythoside I 1177581-50-8

Forsythoside I, a caffeoyl phenylethanoid glycoside (CPG) isolated from the fruits ofForsythia suspense(Thunb.) Vahl, may possesses anti-inflammatory activities.

YN483233 Forsythoside H 1178974-85-0

Forsythoside H, a caffeoyl phenylethanoid glycoside (CPG) isolated from the fruits ofForsythia suspense(Thunb.) Vahl, may possesses anti-inflammatory activities.

YN371192 13-​cis Acitretin D3 1185241-03-5

13-cis Acitretin D3 （Isoacitretin D3） is a deuterium labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin(Ro 10-1670) is a second-generation, systemic retinoid that has...

YN320106 Tesmilifene fumarate 1185241-83-1

Tesmilifene fumarate (DPPE fumarate), an H1C receptorantagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells.

YN350083 MK-2 Inhibitor III 1186648-22-5

MK-2 Inhibitor III (compound 16) is an orally active, selective, and ATP-competitiveMAPKAP-K2 (MK-2)inhibitor with an IC50 of 0.85nM, and is exceptional selectivity against MK-3 (IC50=0.21μM), MK-5 (IC50=0...

YN320435 Omidenepag isopropyl 1187451-19-9

Omidenepag isopropyl is a selectiveEP2receptor agonist. Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration, and Omidenepag is a highly selective EP2 receptor agonist. Omidenepag isoprop...

YN340170 Baricitinib 1187594-09-7

Baricitinib (LY3009104, INCB028050) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Phase 3...

YN340171 Baricitinib phosphate 1187595-84-1

Baricitinib phosphate is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2.

YN370119 MK-8617 1187990-87-9

MK-8617 is an orally active pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1?3 (HIF PHD1?3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.

YN1710004 ABT-702 dihydrochloride 1188890-28-9

ABT-702 is a novel, potent non-nucleoside Adenosine kinase inhibitor with an IC50 of 1.7 nM. It has oral activity in animal models of pain and inflammation.

YN321532 Hydroxyzine D8 1189480-47-4

Hydroxyzine D8 is deuterium labeled Hydroxyzine. Hydroxyzine is ahistamine H1-receptorantagonist.

YN330682 Dupilumab 1190264-60-8

Dupilumab (REGN-668) is a fully human mAb toIL-4 receptor α (IL-4Rα)that inhibits bothIL-4 and IL-13signaling, markedly improved moderate-to-severe atopic dermatitis.

YN310096 EB-47 dihydrochloride 1190332-25-2

EB-47 dihydrochloride, a potent and selectivePARP-1/ARTD-1inhibitor with an IC50 value of 45nM, shows modest potency against ARTD5 with an IC50 value of 410nM. EB-47 mimics the substrate NAD+ and extends from the...

YN410038 MRT67307 1190378-57-4

MRT67307 is a dual inhibitor of theIKKε and TBK-1with IC50s of 160 and 19nM, respectively. MRT67307 also inhibitsULK1 and ULK2with IC50s of 45 and 38nM, respectively. MRT67307 also blocksautophagyin cells.

YN410019 CDDO-dhTFEA 1191265-33-4

CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activatesNrf2 and inhibits the pro-inflammatory transcription factorNF-κB. CDDO-dhTFEA restores hypertension (MAP), increases N...

YN321252 Burixafor hydrobromide 1191450-19-7

Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent antagonist ofCXCR4 and a well water soluble anti-angiogenic drug that is of potential value in treating choroid neovascularization. Burixafor hydr...

YN361079 TRPV antagonist 1 1192871-27-4

TRPV antagonist 1 is a transient receptor potential vanilloid(TRPV)antagonist, with an IC50 of < 250nM.

YN371113 JNJ-42041935 1193383-09-3

JNJ-42041935 is a potent, competitive and selective inhibitor of prolyl hydroxylasePHD; inhibits PHD1, PHD2, and PHD3 with pKi values. of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, respectively.

YN482773 Ligupurpuroside C 1194056-33-1

Ligupurpuroside C is a natural phenylethanoid glycoside isolated from Kudingcha.