YN321903 PAR-4 Agonist Peptide, am... 1228078-65-6

PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 ant...

YN330316 Vesatolimod 1228585-88-3

GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7.

YN320955 AM966 1228690-19-4

AM966 is a high affinity, selective, oralLPA1-antagonist, inhibits LPA-stimulated intracellular calcium release (IC50=17nM).

YN321053 AM095 free acid 1228690-36-5

AM095 is an antagonist of the LPA type 1 receptor with IC50 values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively.

YN481095 hDDAH-1-IN-1 1229238-69-0

hDDAH-1-IN-1 (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor ofhuman dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a Ki of 18 µM.

YN481096 hDDAH-1-IN-1 TFA 1229238-70-3

hDDAH-1-IN-1 TFA (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor ofhuman dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a Ki of 18 µM.

YN440044 BMS-935177 1231889-53-4

BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec fam...

YN330328 APY0201 1232221-74-7

APY0201 is a potentPIKfyveinhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2in the presence of in the presence of [33P]ATP with an IC50 of 5.2nM. APY0201 also inhibitsIL-12/IL-23production.

YN321094 Gemilukast 1232861-58-3

Gemilukast is an orally active and potent dual cysteinyl leukotriene 1 and 2 receptors(CysLT1 and CysLT2)antagonist, with IC50s of 1.7, 25nM for human CysLT1 and CysLT2, respectively.

YN370395 CAY10650 1233706-88-1

CAY10650 is a highly potent cytosolic phospholipase A2α(cPLA2α)inhibitor with an IC50 value of 12nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion.

YN330210 hPGDS-IN-1 1234708-04-3

hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12nM in the Fluorescence Polarization Assay or the EIA assay.

YN330056 LMT-28 1239600-18-0

LMT-28 is an orally active and the first syntheticIL-6inhibitor that functions through direct binding to gp130. LMT-28 shows low toxicity and selectively inhibits IL-6-induced phosphorylation of STAT3, JAK2, and gp130...

YN320402 Brilaroxazine 1239729-06-6

Brilaroxazine (RP5603) is a potent and orally active multimodaldopamine (DA)/serotonin (5-HT)modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki=1.5nM)  and 5-HT2A ...

YN320016 GSK2239633A 1240516-71-5

GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with apIC50 of 7.96 ± 0.11.

YN440372 RN486 1242156-23-5

RN486 is a potent and selective BTK inhibitor with IC50 of 4 nM.

YN370833 BCI 1245792-51-1

BCI ((E)-BCI, compound 1) is an allosteric dual specificity phosphatase (DUSP) inhibitor with EC50 of 13.3 μM and 8.0 μM in cells for DUSP6 and DUSP1, respectively.

YN320726 Mabuterol-D9 1246819-58-8

Mabuterol-D9 is a deuterium labeled Mabuterol. Mabuterol is an agonist of theβ2-adrenergic receptor.

YN410089 Curcumin D6 1246833-26-0

Curcumin D6 (Diferuloylmethane D6) is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiprolife...

YN360701 CRAC intermediate 1 1249343-86-9

CRAC intermediate 1 is a key intermediate in the chemical synthesis of a series of CRAC channel inhibitors, detailed information can be found in Patent WO 2010122089 A1, intermediate 9.

YN370448 Petesicatib 1252637-35-6

Petesicatib is acathepsin Sinhibitor, used in research of immune diseases.