YN372246 N6022 1208315-24-5

N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2.

YN340137 Oclacitinib 1208319-26-9

Oclacitinib is a novelJAKinhibitor. Oclacitinib is most potent at inhibitingJAK1(IC50=10nM).

YN330355 AN-3485 1213827-99-6

AN-3485 is a benzoxaborole analog,Toll-Like Receptor(TLR)inhibitor with IC50 values ranging from 18 to 580nM.

YN300057 Zaurategrast ethyl ester sulf... 1214261-78-5

Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester prodrug of CT7758 , is aα4β1/α4β7integrin antagonist used for the treatment of inflammatory and autoimmune disorders.

YN320656 KAG-308 1215192-68-9

KAG-308 is a potent selective and orally active agonist ofEP4 receptor(a prostagl and in E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows ...

YN330448 Ketorolac D5 1215767-66-0

Ketorolac D5 is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselectiveCOXinhibitor, with IC50s of 20nM for COX-1 and 120nM for COX-2.

YN361091 Lansoprazole Sulfide D4 1216682-38-0

Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an active metabolite of theproton pumpinhibitor Lansoprazole. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tubercul...

YN330442 Mefenamic acid D4 1216745-79-7

Mefenamic acid D4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor ofhCOX-1 and hCOX-2, with IC50s of 40nM and 3μM for hCOX-1 and hCO...

YN321342 Doxylamine D5 succinate 1216840-94-6

Doxylamine D5 succinate is deuterium labeled Doxylamine, which is a first generation antihistamine.

YN370210 Atorvastatin lactone D5 1217749-86-4

Atorvastatin lactone D5 is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a prodrug form of atorvastatin. Atorvastatin is an orally active3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)reductase ...

YN330044 SK1-IN-1 1218816-71-7

SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58nM.

YN321039 MK-7246 1218918-62-7

MK-7246 is a potent and selectiveCRTH2antagonist with a Ki of 2.5±0.5nM.

YN321461 Rebamipide D4 1219409-06-9

Rebamipide D4 (OPC12759 D4) is deuterium labeled Rebamipide. Rebamipide is a mucoprotective agent. Rebamipide inducesCOX-2expression, increasesPGE2levels, and enhances gastric mucosal defense in a COX-2-dependent manner.

YN321115 Cetirizine D4 1219803-84-5

Cetirizine D4 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamineH1-receptorantagonist. Cetirizine...

YN330208 E6446 1219925-73-1

E6446 is a potent and orally acitveTLR7 and TLR9antagonist, used in the research of deleterious inflammatory responses.

YN320600 CCR1 antagonist 9 1220026-26-5

CCR1 antagonist 9 is a potent and selectiveCCR1antagonist with an IC50 of 6.8nM in calcium flux assay.

YN350158 Skepinone-L 1221485-83-1

Skepinone-L is a selective p38α-MAPK inhibitor with IC50 of 5 nM.

YN370868 Evogliptin tartrate 1222102-51-3

Evogliptin tartrate is a potent, orally bioavailable and selectivedipeptidyl peptidase-4 (DPP-4)inhibitor, with antidiabetic activity. Evogliptin tartrate has potential for anti-atherosclerosis therapy that targets arterial inflammat...

YN370142 TPPU 1222780-33-7

TTPU is a soluble epoxide hydrolase (sEH) inhibitor with IC50 values of 37 and 3.7nM for monkey and human sEH, respectively.

YN330297 ATB-346 1226895-20-0

ATB 346, a novel hydrogen sulphide-releasing derivative of naproxen with remarkably reduced toxicity, inhibits COX activity. ATB 346 is an anti-inflammatory agent that induces apoptosis of human melanoma cells.