YN320017 SAR-100842 1195941-38-8

SAR-100842 is a lysophaphatidic acid 1 (LPA1/Edg-2) receptor inhibitor.

YN483106 4''-methyloxy-Daidzin 1195968-02-5

4''-methyloxy-Daidzin (Daidzein 7-O-Β-D-glucoside 4''-O-methylate), an isoflavone methyl-glycoside, is isolated fromCordyceps militarisgrown on germinated soybeans. Isoflavones possess immunomodulating and antiallergic activities.

YN321043 Fiboflapon sodium 1196070-26-4

Fiboflapon sodium (GSK2190915; AM-803) is a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9nM in FLAP binding, an IC50 of 76nM for inhibition ofLTB4in human bloo...

YN372201 PF-3845 1196109-52-0

PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.

YN320437 AZD7594 1196509-60-0

AZD7594 is a potent selective nonsteroidalglucocorticoid receptormodulator, with an IC50 of 0.9nM.

YN250130 Vapendavir diphosphate 1198151-75-5

Vapendavir diphosphate (BTA798 diphosphate) is a potententeroviralcapsid binder (CB). Vapendavir diphosphate (BTA798 diphosphate) possesses potent antiviral activity for enterovirus 71 (EV71) replication, withEC50values of 0.5...

YN360605 Esomeprazole magnesium salt 1198768-91-0

Esomeprazole magnesium salt ((S)-Omeprazole magnesium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of theH+, K+-ATPasein gastric parietal cells. Esomeprazole magnesium ...

YN450040 β-catenin/CBP-IN-1 1198780-38-9

β-catenin/CBP-IN-1 is a potent and selectiveCBP/β-cateninantagonist, extracted from the patent WO2014092154A1. β-catenin/CBP-IN-1 has the potential for the study of liver fibrosis induced by hepatitis virus.

YN250957 Amphotericin B trihydrate 1202017-46-6

Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures ofStreptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity.

YN372198 GPP78 1202580-59-3

GPP78 (CAY10618) is a potentNamptinhibitor with an IC50 of 3.0nM fornicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8nM by inducingauto...

YN410026 B022 1202764-53-1

B022 is a potent and selectiveNF-κB-inducing kinase (NIK)inhibitor with a Ki of 4.2nM. B022 protects liver from toxin-induced inflammation, oxidative stress, and injury.

YN372330 Epacadostat 1204669-58-8

Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO).

YN320993 SRT3109 1204707-71-0

SRT3109 is an antagonist ofCXCR2, with apIC50 of 8.2, and used in the research of chemokine mediated diseases.

YN320682 SRT3190 1204707-73-2

SRT3190 is an antagonist ofCXCR2, used in the research of chemokine mediated diseases.

YN320643 Etrasimod 1206123-37-6

Etrasimod (APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an IC50 value of 1.88nM in CHO cells.

YN340194 Solcitinib 1206163-45-2

Solcitinib is an inhibitor of JAK1 with an IC50 of 8-9 nM, and shows 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively.

YN330285 AM679 1206880-66-1

AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2nM/0.6nM/154nM for FLAP binding/hLA/hWB respectively.

YN330161 GSK2245035 1207629-49-9

GSK2245035 is a highly potent and selective intranasalToll-Like receptor 7 (TLR7)agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 haspEC50s of 9.3 and 6.5 for IFNα and TFNα....

YN380128 CaMKII-IN-1 1208123-85-6

CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.

YN480410 Tepilamide fumarate 1208229-58-6

Tepilamide fumarate (XP-23829) is an oral fumaric acid ester, acts as a prodrug of monomethyl fumarate, and is used in the research of moderate to severe chronic plaque psoriasis.