YN360355 GSK-5498A 1253186-49-0

GSK-5498A is a selective small molecule blocker ofCARC(IC50, 1μM); inhibits mediator release from mast cells, and pro-inflammatory cytokine release from T-cells in a variety of species.

YN360348 GSK-7975A 1253186-56-9

GSK-7975A is a potent and orally availableCRACchannel inhibitor.

YN320079 Setogepram sodium salt 1254472-97-3

Setogepram sodium salt (PBI-4050 sodium salt) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Setogepram sodium salt decreases renal, liver and pancreatic fibrosis. Setogepram sod...

YN260212 Azido-PEG4-C2-acid 1257063-35-6

Azido-PEG4-C2-acid a PEG-based PROTAClinker can be used in the synthesis of vRucaparib-TP4. Azido-PEG4-C2-acid is also a non-cleavable 4 unit PEGADClinker used in the synthesis of antibody-drug conjugates (ADC...

YN320060 BMS-986020 1257213-50-5

BMS-986020 (AM152, AP-3152 free acid) is a potent and selective antagonist of lysophosphatidic acid receptor 1 (LPA1). BMS-986020 inhibits bile acid and phospholipid transporters with IC50 of 4.8 μM, 6.2 μM, and 7.5 μM ...

YN480798 ACT-389949 1258417-54-7

ACT-389949 is a first-in-class, potent and selective and agonist offormyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3nM for FPR2/ALX internalization into monocytes. ACT-389949 has p...

YN330148 Sparstolonin B 1259330-61-4

Sparstolonin B acts as a selectiveTLR2 and TLR4antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities.

YN360586 Funapide 1259933-16-8

Funapide (TV 45070; XEN402) is a potentSodium Channel Nav1.7inhibitor.

YN480901 4-Hydroxyphenyl Carvedilol D... 1261395-96-3

4-Hydroxyphenyl Carvedilol D5 is the deuterium labeled 4-Hydroxyphenyl Carvedilol.

YN321281 INCB3344 1262238-11-8

INCB3344 is a potent, selective and orally bioavailableCCR2antagonist with IC50 values of 5.1nM (hCCR2) and 9.5nM (mCCR2) in binding antagonism and 3.8nM (hCCR2) and 7.8nM (mCCR2) in antagonism of chemotaxis...

YN321166 Cenerimod 1262414-04-9

Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7nM.

YN350268 OVA-E1 peptide TFA 1262750-80-0

OVA-E1 peptide TFA, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.

YN360308 GSK205 1263068-83-2

GSK205 is a potent, selective TRPV4 antagonist with an IC50 of 4.19 μM for inhibitingTRPV4-mediated Ca2+influx.

YN371609 DHODH-IN-11 1263303-95-2

DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weakdihydroorotate dehydrogenase (DHODH)inhibitor with apKaof 5.03.

YN340065 Delgocitinib 1263774-59-9

Delgocitinib (JTE-052) is a specificJAKinhibitor with IC50s of 2.8, 2.6, 13  and  58nM for JAK1, JAK2, JAK3  and  Tyk2, respectively.

YN483170 5,6-Didehydroginsenoside Rd 1268459-68-2

5,6-Didehydroginsenoside Rd is a dammarane-type saponin isolated from the dried roots ofPanax notoginseng.

YN330150 Maresin 1 1268720-28-0

Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity .

YN480647 TXNIP-IN-1 1268955-50-5

TXNIP-IN-1 isTXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complexinhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associat...

YN440053 BTK IN-1 1270014-40-8

BTK IN-1 (SNS062 analog) is a potentBTKinhibitor, with an IC50 of <100nM.

YN370907 APX-115 free base 1270084-92-8

APX-115 free base (Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-182...