YN310016 Cl-amidine hydrochloride 1373232-26-8

Cl-amidine hydrochloride is an orally activepeptidylarginine deminase (PAD)inhibitor, with IC50 values of 0.8μM, 6.2μM and 5.9μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine hydrochloride induces apoptosis in...

YN250302 M4284 1373346-85-0

M4284 is a selective and orally active biphenyl mannosideFimHantagonist. M4284 has activities against different UPEC (Urinary tract infections (UTI) caused by uropathogenicE. coli) strains in different host genetic background...

YN480726 ARN 077 1373625-34-3

ARN 077 is a potent and selectiveN-acylethanolamine acid amidase (NAAA)inhibitor with an IC50 of 7nM for human NAAA. ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broa...

YN300022 THI0019 1378532-99-0

THI0019 is a potentintegrin α4β1 (VLA-4)agonist with anEC50range of 1-2μM. THI0019 induces stem/progenitor cells adhesion. THI0019 also regulates adhesion mediated by α4β7, α5β1 and αLβ2.

YN320452 CRTh2 antagonist 1 1379445-54-1

CRTh2 antagonist 1 is aCRTh2antagonist with an IC50 of 89nM。

YN320120 CCR2 antagonist 3 1380100-86-6

CCR2 antagonist 3 is a chemokine receptor 2(CCR2)antagonist.

YN360085 GAL-021 1380341-99-0

GAL-021 a new intravenousBKCa-channelblocker.

YN372524 KML29 1380424-42-9

KML29 is an extremely selective, orally active and irreversibleMAGLinhibitor, with IC50 values of 15nM, 43nM and 5.9nM for mouse, rat and human MAGL, respectively. KML29 exhibits minimal cross-reactivity toward othe...

YN320061 BMS-986020 sodium 1380650-53-2

BMS-986020 sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist. BMS-986020 sodium inhibits bile acid and phospholipid transporters with IC50s of 4.8 µM, 6.2 µM, and 7.5 µM for BSEP, MRP4,...

YN360144 NecroX-5 1383718-29-3

NecroX-5 is a derivative of the NecroX, reduces intracellularcalciumconcentration, and possesses anti-inflammatory and anti-cancer activity.

YN480221 Complement factor D-IN-1 1386455-76-0

Complement factor D-IN-1 is a potent and selectivesmall-molecule reversible factor dinhibitor, with IC50s of 0.006 and 0.05μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively.

YN480514 KRN2 bromide 1390654-28-0

KRN2 (bromide) is a selective inhibitor ofnuclear factor of activated T cells (NFAT5), with an IC50 of 0.1μM.

YN370081 Roflumilast Impurity E 1391052-76-8

Roflumilast Impurity E is the impurity of Roflumilast. Roflumilast(Daliresp) is a drug which acts as a selective and long-acting inhibitor of the enzymePDE-4with an IC50 value of 0.8nM.

YN370906 APX-115 1395946-75-4

APX-115 (Ewha-18278) is a potent, orally active panNADPH oxidase (Nox)inhibitor with Kivalues of 1.08μM, 0.57μM, and 0.63μM forNox1,Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury.

YN480168 NE 52-QQ57 1401728-56-0

NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293...

YN260094 PEG4-aminooxy-MMAF 1415246-35-3

PEG4-aminooxy-MMAF is adrug-linker conjugate for ADCwith potent antitumor activity by using the potent antitubulin agent MMAF, linked via the noncleavable PEG4.

YN360693 (R)-BPO-27 1415390-47-4

(R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitiveCFTRinhibitor with an IC50 of 4nM.

YN372662 GSK256066 Trifluoroacetate 1415560-64-3

GSK256066 Trifluoroacetate is a selective and high-affinityphosphodiesterase 4 (PDE)inhibitor, with an IC50 of 3.2 pM for PDE4B. GSK256066 Trifluoroacetate is developed for the research of chronic obstructive pulmonary ...

YN320986 PF-543 Citrate 1415562-83-2

PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitiveSPHK1inhibitor with an IC50 of 2nM and a Ki of 3.6nM. PF-543 Citrate is >100-fold selectivity ...

YN440027 Evobrutinib 1415823-73-2

Evobrutinib is a highly selective BTK inhibitor with an IC50 of 37.9 nM. It has potential anti-neoplastic activity.