YN350049 PF-3644022 1276121-88-0

PF-3644022 is a potent, selective, orally active and ATP-competitiveMAPKAPK2 (MK2)inhibitor with an IC50 of 5.2nM and a Ki of 3nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK)with I...

YN260089 CL2A-SN-38 1279680-68-0

CL2A-SN-38 is adrug-linker conjugatecomposed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effect...

YN372494 SGK1-IN-1 1279829-87-6

SGK1-IN-1 is a highly active and selective inhibitor ofSGK-1, with an IC50 of 1nM.

YN484158 Influenza Matrix Protein (6... 1286245-45-1

Influenza Matrix Protein (61-72) is a peptide fragment derived from matrix protein of influenza viruses, corresponds to amino acids 61-72. Influenza Matrix Protein (61-72) is a specific epitope which can induce CD4+T-cell response.

YN360233 Licogliflozin 1291094-73-9

Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor.

YN480641 SPR inhibitor 3 1292285-54-1

SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74nM) and efficiently reduces biopterin levels ...

YN410031 TBK1/IKKε-IN-2 1292310-49-6

TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.

YN320535 CCR1 antagonist 8 1295298-26-8

CCR1 antagonist 8 (compound 19n), a third azaindazole series compound, is aCCR1antagonist, with an IC50 of 1.8nM in Ca2+flux assay.

YN310193 Bromodomain inhibitor-8 1300031-70-2

Bromodomain inhibitor-8 (Intermediate 21) is aBET bromodomaininhibitor for treating autoimmune and inflammatory diseases.

YN320137 CHPG sodium salt 1303993-73-8

CHPG sodium salt is a selectivemGluR5agonist, and attenuates SO2-induced oxidative stress and inflammation throughTSG-6/NF-κBpathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury ...

YN420172 MSC2360844 1305267-37-1

MSC2360844 is a potent, orally active and selectivePI3Kδinhibitor, with an IC50 of 145nM. MSC2360844 shows highly selective against a panel of 278 additional kinases.

YN320570 Ozanimod 1306760-87-1

Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3.

YN440228 ITK inhibitor 2 1309784-09-5

ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor extracted from patent WO2011065402A1, compound 4, with an IC50 of 2nM.

YN480429 (±)-CPSI-1306 1309793-47-2

(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor(MIF).

YN340219 Upadacitinib 1310726-60-3

Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200nM) in cellular assa...

YN370839 HA155 1312201-00-5

HA-155 is a potent and selectiveautotaxin (ATX)inhibitor with an IC50 of 5.7nM .

YN440286 ARRY-382 1313407-95-2

ARRY-382 is a potent, oral and highly selective inhibitor ofCSF1R/c-Fmswith an IC50 of 9nM. ARRY-382 can be used for the research of advanced or metastatic cancers.

YN483835 WKYMVM TFA 1313730-09-4

WKYMVM (TFA) is a potent N-formyl peptide receptor (FPR1) and FPRL1/2agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH...

YN320259 CCR2 antagonist 4 hydrochlo... 1313730-14-1

CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) is a potent and specificCCR2antagonist, with IC50s of 180nM for CCR2b. CCR2 antagonist 4 hydrochloride potently inhibits MCP-1-induced chemotaxis with an...

YN350123 MK2-IN-1 hydrochloride 1314118-94-9

MK2-IN-1 hydrochloride is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.