YN360694 BPO-27 racemate 1314873-02-3

BPO-27 racemate is a potentCFTRinhibitor with an IC50 of 8nM.

YN350159 NG25 1315355-93-1

NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively.

YN310134 VTX-27 1321924-70-2

VTX-27 is a selective protein kinase C θ(PKC θ)inhibitor, with Kisof 0.08nM and 16nM for PKC θ and PKC δ.

YN430003 Iberdomide 1323403-33-3

Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay.

YN320648 S1P1 Agonist III 1324003-64-6

S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18nM; no activity on S1P3. IC50 value: 18nM(EC50)

YN330396 (S)-(+)-Ibuprofen D3 1329643-44-8

(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibitsCOX-1 and COX-2activity with IC50s of 2.1μM and 1.6μM. (S)-(+)-I...

YN360211 Ethacrynic acid D5 1330052-59-9

Ethacrynic acid D5 is a deuterium labeled Ethacrynic acid. Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor ofglutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor ofNF-kB-signalingpathway, and...

YN330430 Nimesulide D5 1330180-22-7

Nimesulide D5 is a deuterium labeled Nimesulide. Nimesulide is a selectiveCOX-2 inhibitor, with IC50s of 70nM-70μM in a time-dependent manner, but it shows no effect on COX-1 (IC50>100μM). Nimesulide has potent anti-infl...

YN360662 PF-4840154 1332708-14-1

PF-4840154 is a potent, selective agonist of the rat and humanTrpA1channel with EC50s of 97 and 23nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse.

YN270223 (Rac)-Benpyrine 1333714-43-4

Benpyrine racemate ((Rac)-Benpyrine) is a potent, highly specific and orally active inhibitor of TNF-α and attenuates TNF-α-induced inflammation, thereby reducing liver and lung injury.

YN320109 GSK682753A 1334294-76-6

GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6nM.

YN330124 Mito-TEMPO 1334850-99-5

Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic with superoxide and alkyl radical scavenging properties.

YN371554 SR1001 1335106-03-0

SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively.

YN270159 GSK2593074A 1337531-06-2

GSK2593074A (GSK’074) is anecroptosisinhibitor with dual targeting ability to bothRIP1 and RIP3.

YN320516 Misoprostol acid D5 1337917-44-8

Misoprostol acid D5 is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue ofprostagl and in E1 (PGE1), extensively absorbed, and undergoes rapid de-es...

YN320712 PF-4136309 1341224-83-6

PF-4136309 is a potent, selective, and orally bioavailableCCR2antagonist, with IC50s of 5.2nM, 17nM and 13nM for human, mouse and rat CCR2.

YN480392 α,β-Methylene ATP trisod... 1343364-54-4

α,β-Methylene ATP trisodium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor lig and .

YN321052 AM095 1345614-59-6

AM095 is a selectiveLPA1receptor antagonist. TheIC50for AM095 antagonism of LPA-induced calcium flux of human or mouse LPA1-transfected CHO cells is 0.025 and 0.023μM, respectively.

YN330209 E6446 dihydrochloride 1345675-25-3

E6446 is a specific Toll-like receptor 9 inhibitor.

YN360112 EIPA hydrochloride 1345839-28-2

EIPA hydrochloride (L593754 hydrochloride) is aTRPP3 channelinhibitor with an IC50 of 10.5μM. EIPA hydrochloride also inhibitsNa+/H+-exchanger(NHE) and macropinocytosis .