YN320121 S1p receptor agonist 1 1514888-56-2

S1p receptor agonist 1 is a potent and orally activeS1P receptoragonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83nM). S1p receptor agonist 1 has the potential for the study of arthritis and EAE (expe...

YN370977 ML355 1532593-30-8

ML355 is a potent and selective inhibitor of human 12-Lipoxygenase with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases.

YN330093 Avelumab 1537032-82-8

Avelumab is a fully human IgG1 anti-PD-L1monoclonal antibody with potential antibody-dependent cell-mediated cytotoxicity.

YN370857 SBFI-26 1541207-06-0

SBFI-26 is a selective and competitive inhibitor of fatty acid binding proteinsFABP5 and FABP7, with Kis of 0.9 µM and 0.4 µM for FABP5 and FABP7, respectively. SBFI-26 produces anti-nociceptive and anti...

YN372542 ZED-1227 1542132-88-6

ZED-1227 is a specific and oraltransglutaminase 2 (TG2)inhibitor, with an IC50 of 45nM. ZED-1227 can block inflammation-induced TG2 expression and activity. ZED-1227 can be used for the research of celiac disease (CeD...

YN440041 Btk inhibitor 2 1558036-85-3

Btk inhibitor 2 is a BTK inhibitor.

YN310145 BJE6-106 1564249-38-2

BJE6-106 (B106) is a potent, selective 3rdgenerationPKCδinhibitor with an IC50 of 0.05μM and targets selectivity over classical PKC isozyme PKCα (IC50=50μM). BJE6-106 (B106) induces caspase-dependentapoptosis. ...

YN370930 PS10 1564265-82-2

PS10 is a novel, potent and ATP-competitive pan-PDKinhibitor, inhibits all PDK isoforms with IC50 of 0.8μM, 0.76μM, 2.1μM and 21.3μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affi...

YN440222 PRN694 1575818-46-0

PRN694 is an irreversible, highly selective and potent covalentinterleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK)dual inhibitor with IC50s of 0.3nM and 1.4nM, respectively. PRN694 exhibits e...

YN270110 GSK2983559 free acid 1579965-12-0

GSK2983559 is a potent inhibitor of receptor interacting protein 2 (RIP2) kinase with good kinase specificity.

YN290462 KIRA6 1589527-65-0

kira6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 μM. It dose-dependently inhibits IRE1α(WT) kinase activity, XBP1 RNA cleavage, Ins2 RNA cleavage and oligomerization.

YN330268 GSK717 1595278-21-9

GSK717 is a potent, selectiveNOD2(nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400nM for MDP-stimulated IL-8 secretio...

YN320430 PS372424 hydrochloride 1596362-29-6

PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific humanCXCR3agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammati...

YN320506 ML401 1597489-14-9

ML401, a potent chemical probe, selectively antagonizesEBI2(also known asGPR183) with an IC50 of 1.03nM. ML401 displays activity in a chemotaxis assay (IC50=6.24nM). ML401 shows good stability and no toxicity.

YN320575 NIBR189 1599432-08-2

NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16nM(Binding) and 11nM (Functional). NIBR189 is a potent and selective EBI2 antagonist with im...

YN270186 GSK-843 1601496-05-2

GSK-843 (GSK'843) is areceptor-interacting protein kinase 3 (RIP3 or RIPK3)inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6nM, and inhibits kinase activity with an IC50 of 6.5nM.

YN410078 AZD3264 1609281-86-8

AZD3264 is a novel IKK2 inhibitor.

YN330156 BMS-986165 1609392-27-9

BMS-986165 is a highly selective, orally bioavailable allostericTYK2inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0nM)  and  blocks receptor-...

YN410043 Aeruginosin 865 1611990-01-2

Aeruginosin 865, isolated from terrestrial cyanobacteriumNostoc sp. Lukešová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation ofNF-kBto th...

YN320122 BAR502 1612191-86-2

BAR502 is a dualFXR and GPBAR1agonist with IC50 values of 2μM and 0.4μM, respectively.