YN320531 GB-88 1416435-96-5

GB-88 is an oral, selective non-peptide antagonist ofPAR2, inhibitsPAR2activated Ca2+release with an IC50 of 2 µM.

YN370451 Cilofexor 1418274-28-8

Cilofexor (GS-9674) is a potent, selective and orally active nonsteroidalFXRagonist with an EC50 of 43nM. Cilofexor has anti-inflammatory and antifibrotic effects. Cilofexor has the potential for primary sclerosing cholangiti...

YN483202 2,3,4,5-Tetracaffeoyl-D-Glu... 1419478-52-6

2,3,4,5-Tetracaffeoyl-D-Glucaric acid is a caffeoyl-D-glucaric acid derivative isolated from the GenusGnaphalium.

YN480808 WS3 1421227-52-2

WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

YN480807 WS6 1421227-53-3

WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

YN340020 PF-06263276 1421502-62-6

PF-06263276 (PF 6263276) is a potent and selectivepan-JAKinhibitor, with IC50s of 2.2nM, 23.1nM, 59.9nM and 29.7nM for JAK1, JAK2, JAK3 and TYK2, respectively.

YN270170 CDKI-73 1421693-22-2

CDKI-73 (LS-007) is a potent CDK inhibitor in vitro with IC50 of 8.17 nM, 3.27 nM, 8.18 nM, and 5.78 nM for CDK1, CDK2, CDK4, and CDK9, respectively. CDKI-73 induces apoptosis in cancer cells. CDKI-73 is a...

YN370863 TMP920 1421837-45-7

TMP920 is a highly potent and selectiveRORγtantagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC50 of 0.03μM.

YN370229 TMP780 1422053-03-9

TMP780 is an inverse agonist ofRORγtwith an IC50 of 13nM. RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.

YN370228 TMP778 1422053-04-0

TMP778 is a potent and selevtiveRORγtinverse agonist, with an IC50 of 7nM in FRET assay.

YN372484 TC-S 7009 1422955-31-4

TC-S 7009 is a potent and selectiveHIF-2αinhibitor with aKdof 81nM. TC-S 7009 is more selective forHIF-2αthan HIF-1α (Kd≫ 5μM). TC-S 7009 disruptsHIF-2αheterodimerization, decreases DNA-binding activity, ...

YN420079 IPI-3063 1425043-73-7

IPI-3063 is a potent and selective p110δ inhibitor with biochemical IC50 of 2.5?±?1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.

YN260209 Azido-PEG5-acid 1425973-16-5

Azido-PEG5-acid is a non-cleavable 5 unit PEGADClinker used in the synthesis of antibody-drug conjugates (ADCs), such as the conjugate CPT-APO (CPT: Camptothecin (HY-16560)).

YN371100 GSK805 1426802-50-7

GSK805 is a potent, orally bioavailable, and CNS penetrantRORγtinhibitor with pIC50 of 8.4 and >8.2 for RORγ FRET assay and Th17 assay.

YN321993 TRAP-6 amide TFA 1426807-16-0

TRAP-6 amide TFA is aPAR-1 thrombin receptoragonist peptide.

YN480329 E6130 1427058-33-0

E6130 is an orally active and highly selectiveCX3CR1modulator, that may be effective for treatment of inflammatory bowel disease.

YN440449 DDR1-IN-2 1429617-90-2

DDR1-IN-2 is a potent inhibitor ofdiscoidin domain receptor 1(DDR1), with an IC50 of 13.1nM, and also less potently inhibits DDR2, with an IC50 of 203nM.

YN370382 LY2955303 1433497-19-8

LY2955303 is a potent and selectiveretinoic acid receptor gamma(RARγ) antagonist with a Ki of 1.09nM.

YN480112 HCH6-1 1435265-06-7

HCH6-1 is a competitive antagonist of Formyl peptide receptor 1 (FPR1), an emerging therapeutic target for the discovery of drugs to treat neutrophilic inflammatory diseases. HCH6-1 is a selectiveFPR1inhibitor and has protect...

YN483836 WKYMVM-NH2 TFA 1435781-74-0

WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NA...