YN483439 Mogroside II-​A 1613527-65-3

Mogroside II-​A is a natural product isolated fromSiraitia grosvenorii.

YN310283 SGC-CBP30 1613695-14-9

SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2...

YN330170 ARN-3236 1613710-01-2

ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cel...

YN420089 UCB9608 1616413-96-7

UCB9608 is a potent, selective and orally activePI4KIIIβinhibitor, with an IC50 of 11nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinet...

YN371730 AQX-435 1619983-52-6

AQX-435 is a potentSHIP1 phosphataseactivator. AQX-435 reduces PI3K activation downstream of the B-cell receptor (BCR) and induces apoptosis of malignant B cells, and reduces lymphoma growth.

YN330068 TLR7/8 agonist 1 dihydrochl... 1620278-72-9

TLR7/8 agonist 1 dihydrochloride is a toll-like receptorTLR7/TLR8dual-agonistic imidazoquinoline.

YN420173 MSC2360844 hemifumarate 1621688-31-0

MSC2360844 hemifumarate is a potent, orally active and selectivePI3Kδinhibitor, with an IC50 of 145nM. MSC2360844 hemifumarate shows highly selective against a panel of 278 additional kinases.

YN270035 GSK2982772 1622848-92-3

GSK2982772 is an ATP competitive receptor-interacting protein-1 (RIP1) kinase inhibitor with the IC50 value of 1 nM. It has exquisite kinase specificity and excellent activity in blocking many TNF-dependent cellular response...

YN270004 GSK481 1622849-58-4

GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.

YN340064 Abrocitinib 1622902-68-4

PF-04965842 is a potent JAK1 inhibitor with IC50s of 29 nM, 803 nM, > 10 000 nM and 1250 nM for JAK1, JAK2, JAK3 and tyrosine kinase (TYK) 2, respectively.

YN440012 GSK3179106 1627856-64-7

GSK3179106 is a potent, selective, and gut-restricted pyridone hinge binder small molecule RET kinase inhibitor with a RET IC50 of 0.3 nM and is efficacious in vivo.

YN370197 Ziritaxestat 1628260-79-6

Ziritaxestat (GLPG1690) is a selective autotaxin inhibitor with an IC50 of 131 nM and Ki of 15 nM.

YN360357 CFTR corrector 2 1628416-28-3

FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.

YN372569 PKR-IN-2 1628428-01-2

PKR-IN-2 is a pyruvate kinase isoformPKRactivator extracted from patent WO2014139144A1, compound 160. PKR-IN-2 can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune...

YN350091 MW-150 1628502-91-9

MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor ofp38α MAPKwith a Ki of 101nM. MW-150 inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK...

YN370198 KZR-504 1629052-78-3

KZR-504 is a highly selective inhibitor of immunoproteasome low molecular mass polypeptide 2(LMP2), with IC50s of 51nM, 4.274μM for LMP2 and LMP7, respectively. KZR-504 is of interest for the treatment of autoimmune di...

YN290146 Kira8 1630086-20-2

Kira8 (AMG-18) is a mono-selectiveIRE1αinhibitor that allosterically attenuatesIRE1α RNase activitywith an IC50 of 5.9nM.

YN330222 ADU-S100 1638241-89-0

ADU-S100 (MIW815), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.

YN330223 ADU-S100 disodium salt 1638750-95-4

ADU-S100 disodium salt (MIW815 disodium salt) is an activator of stimulator of interferon genes (STING).

YN330224 ADU-S100 ammonium salt 1638750-96-5

ADU-S100 ammonium salt (MIW815 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.