Chemical structure
Cat.No.
Product Name
CAS no.
Target
Emavusertib (CA-4948) is a potent and orally bioavailable inhibitor of interleukin-1 receptor-associated kinase 4/FMS-like Tyrosine Kinase 3 (IRAK4/FLT3) with anti-tumor activity.
YN430058 PROTAC RIPK degrader... 1801547-16-9
PROTAC RIPK degrader-2 is a nonpeptidicPROTACwhich potently targets serine-threonine kinaseRIPK2 and has highly selective for RIPK2 degradation.
YN370123 Brensocatib 1802148-05-5
Brensocatib (AZD7986) is an oraldipeptidyl peptidase 1(DPP1) inhibitor with pIC50s of 6.85, 7.6, 7.7, 7.8, and 7.8 in human, mouse, rat, dog and rabbit, respectively.
YN310109 BB-Cl-Amidine 1802637-39-3
BB-Cl-Amidine is a peptidylarginine deminase(PAD)inhibitor.
YN250824 Contezolid acefosamil 1807497-11-5
Contezolid acefosamil (MRX-4) is the orally active prodrug of the active antimicrobial metabolite Contezolid (MRX-I), an oxazolidinone which shows potent in vitro activity against various multidrug-resistant Gram-positive bacteria...
YN260018 Bis-PEG1-PFP ester 1807539-02-1
PEG4-SPDP is a cleavableADC linkerused for the antibody-drug conjugates (ADCs).
YN350196 PF-06260933 1811510-56-1
PF-6260933 is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity.
YN1710030 PF-06650833 1817626-54-2
PF-06650833 is a potent, selective and orally active inhibitor ofinterleukin-1 receptor associated kinase 4 (IRAK4)with IC50s of 0.2 and 2.4nM in the cell and PBMC assay, respectively. PF-06650833 is used to treat disea...
YN1710015 PF-06426779 1817628-40-2
PF-06426779 is a potent and selective inhibitor ofinterleukin‑1 receptor associated kinase 4 (IRAK4), with an IC50 of 0.3nM.
YN330049 BMS-1166 1818314-88-3
BMS-1166 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 interaction with an IC50 of 1.4 nM.
EHP-101 (VCE-004.8) is an orally active, specificPPARγ and CB2receptor dual agonist. EHP-101 inhibitsprolyl-hydroxylases (PHDs) and activates theHIFpathway. EHP-101, a semi-synthetic multitarget cannabinoquinoid, h...
YN1710003 IRAK4-IN-1 1820787-94-7
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7nM.
YN330101 CU-T12-9 1821387-73-8
CU-T12-9 is a specificTLR1/2agonist withEC50of 52.9nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, no...
YN330052 IL-15-IN-1 1831830-20-6
IL-15-IN-1 is a potent and selectiveInterleukin 15 (IL-15)inhibitor, inhibiting the proliferation of IL-15-dependent cells with an IC50 of 0.8μM.
MLT-748 is a potent, selective and allosteric inhibitor ofMALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5nM.
TH1020 is a potent and selectivetoll-like receptor 5 (TLR5)/flagellin complexantagonist with an IC50 of 0.85μM. TH1020 inhbits flagellin-inducedTLR5signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 ...
YN330137 IRAK4-IN-4 1850276-58-2
IRAK4-IN-4 (compound 15) is an inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) and cyclic GMP-AMP synthase (cGAS) with IC50 of 2.8 nM and 2.1 nM, respectively.
YN330350 Chloroquine D5 1854126-41-2
Chloroquine D5 is deuterium labeled Chloroquine. Chloroquine is anantimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is anautophagy and toll-like receptors (TLRs)inhibitor....
TAK-981 is a first in class and selective inhibitor of theSUMOylationenzymatic cascade, with potential immune-activating and antineoplastic activities.
YN430179 Cereblon modulator 1 1860875-51-9
CC-90009 is a novel cereblon (CRBN) E3 ligase modulator and specifically targets GSPT1 (G1 to S phase transition 1) for proteasomal degradation.
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