YN320327 ROS 234 dioxalate 1781941-93-2

ROS 234 dioxalate is a potentH3antagonist, with apKBof 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and aED50of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 diox...

YN370384 PAT-505 1782070-22-7

PAT-505 is a potent, selective, noncompetitive and orally availableautotaxininhibitor, with an IC50 of 2nM in Hep3B cells, 9.7nM in human blood and 62nM in mouse plasma.

YN320260 C-021 dihydrochloride 1784252-84-1

C-021 dihydrochloride is a potentCC chemokine receptor-4 (CCR4)antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140nM and 39nM, respectively. C-021 effectively preven...

YN350002 TA-02 1784751-19-4

TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM. TA-02 especially inhibits TGFBR-2.

YN450039 CK1-IN-1 1784751-20-7

CK1-IN-1 is acasein kinase 1 (CK1)inhibitor extracted from patent WO2015119579A1, compound 1c, hasIC50s of 15nM, 16nM, 73nM for CK1δ, and CK1ε, p38σ MAPK, respectively.

YN440229 Remibrutinib 1787294-07-8

Remibrutinib (LOU064) is a potent, highly selective covalent inhibitor of bruton tyrosine kinase (BTK) with IC50 of 1.3 nM, 2.5 nM and 18 nM for BTK, FcγR-induced IL8 and anti-IgM/IL4-induced CD69, respectively. R...

YN330671 AMY-101 TFA 1789738-04-0

AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the centralcomplement component C3(KD= 0.5nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammato...

YN340015 PF-06651600 1792180-81-4

PF-06651600 is a potent and irreversible JAK3-selective inhibitor with an IC50 of 33.1 nM but without activity (IC50 > 10 000 nM) against JAK1, JAK2, and TYK2.

YN321111 Alcaftadine-D3 1794775-80-6

Alcaftadine-D3 (R89674-D3) is a deuterium labeled Alcaftadine. Alcaftadine (HY-17039) is a H1 histamine receptor antagonist.

YN320746 Rupatadine D4 fumarate 1795153-63-7

Rupatadine D4 fumarate (UR-12592 D4 fumarate) is a deuterium labeled Rupatadine fumarate. Rupatadine Fumarate (UR-12592 Fumarate) is a potent dualPAF/H1antagonist with Kiof 0.55/0.1μM(rabbit platelet membranes/guinea pig c...

YN480409 Parimifasor 1796641-10-5

Parimifasor (LYC30937) is an immunomodulator, with anti-inflammatory activity.

YN340074 Tyk2-IN-5 1797432-62-2

Tyk2-IN-5 (compound 6) is a highly potent, selective and orally activeTyk2inhibitor and targets the JH2 domain, with a Ki of 0.086nM for Tyk2 JH2 and an IC50 of 25nM for IFNα. Highly effective in inhibiting IFNγ...

YN440251 BIIB068 1798787-27-5

BIIB068 is a potent, selective, reversible and orally activeBTKinhibitor with an IC50 of 1nM and aKdof 0.3nM. BIIB068 shows more >400-fold selective forBTKthan other kinases. BIIB068 has the potential for autoimmu...

YN371773 LTA4H-IN-1 1799681-85-8

LTA4H-IN-1 is a potent inhibitor ofleukotriene A4 hydrolase (LTA4H)extracted from patent WO2015092740A1, example 29, has an IC50 of 2nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorde...

YN410004 KI696 isomer 1799974-69-8

KI696 isomer is the less active isomer of KI696 (HY-101140). KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction.

YN410003 KI696 1799974-70-1

KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of theKEAP1/NRF2interaction.

YN440121 Lanraplenib 1800046-95-0

Lanraplenib (GS-9876, GS-SYK) is a potent, highly selective and orally active inhibitor of Spleen Tyrosine Kinase (SYK) with IC50 of 9.5 nM. Lanraplenib inhibits SYK activity in platelets via the glycoprotein ...