YN340138 Oclacitinib maleate 1640292-55-2

Oclacitinib(PF 03394197) is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM. It does not inhibit a panel of 38 non-JAK kinases.

YN330060 TLR7 agonist 2 1642857-69-9

TLR7 agonist 2 is a potent and selectiveToll-like Receptor 7(TLR7) agonist with aLECof 0.4μM.

YN440048 BMS-986142 1643368-58-4

BMS-986142 is a potent and highly selective reversible inhibitor ofBruton's tyrosine kinase(BTK) with an IC50 of 0.5nM.

YN330207 LNP023 1644670-37-0

LNP023 is an orally bioavailable, highly potent and highly selectivefactor Binhibitor. LNP023 shows direct, reversible, and high-affinity binding to human factor B with aKDof 7.9nM. LNP023 inhibits factor B with an IC50...

YN320523 SX-682 1648843-04-2

SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity.

YN310013 GSK484 hydrochloride 1652591-81-5

GSK484 HCl, a benzoimidazole derivative, is a selective and reversible inhibitor of peptidylarginine deiminase 4 (PAD4) with IC50 of 50 nM in the absence of Calcium.

YN410018 NIK SMI1 1660114-31-7

NIK SMI1 is a potent, selective NF-κB inducing kinase (NIK) inhibitor, which inhibits NIK-catalyzed hydrolysis of ATP to ADP with IC50 of 0.23±0.17nM.

YN320513 TAK-615 1664335-55-0

TAK-615 is a negative allosteric modulator (NAM) of theLPA1receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kdhigh affinity of 1.7nM and Kdlow affinity of 14.5nM).

YN260199 Azido-PEG9-acid 1670249-37-2

Azido-PEG9-acid is a non-cleavable 9 unit PEGADClinker used in the synthesis of antibody-drug conjugates (ADCs).

YN310147 MS402 1672684-68-2

MS402 is aBD1-selectiveBET BrDinhibitor with Kis of 77nM, 718nM, 110nM, 200nM, 83nM, and 240nM forBRD4(BD1),BRD4(BD2),BRD3(BD1),BRD3(BD2),BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks ...

YN330028 PD-1-IN-1 1673534-76-3

PD-1-IN-1 is an inhibitor of programmed cell dealth-1 (PD-1) extracted from patent WO2015033299A1, compound example 4. PD-1-IN-1 can be used as immune modulator.

YN310173 DS-437 1674364-87-4

DS-437 is a dualPRMT5/7inhibitor (IC50s of PRMT5/7=6μM). DS-437 is selective for PRMT5 and PRMT7 over 29 other human protein-, DNA-, and RNA-methyltransferases. DS-437 is a S-adenosylmethionine (SAM)-...

YN330379 BMS-1 1675201-83-8

PD-1/PD-L1 inhibitor 1 is a small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of 6 nM.

YN372577 GNE-6468 1677668-27-7

GNE-6468 is a potent and selectiveRORγ(RORc)agonists with an EC50 value of 13nM for HEK-293 cell.

YN1710010 BAY-545 1699717-32-2

BAY-545 is a potent and selectiveA2Badenosine receptorantagonist, with an IC50 of 59nM. BAY-545 also exhibitsIC50s of 66, 400, 280nM for human, mouse, rat A2Badenosine receptor in cells, respectively, and aKiof 97nM fo...

YN420033 PI3Kδ-IN-2 1702816-75-8

PI3Kδ-IN-2 is a potent and selective inhibitor ofPI3Kδextracted from patent WO 2015055071 A1, compound 10; has an IC50 of 6.4nM.

YN330083 AX-024 hydrochloride 1704801-24-0

AX-024 blocks the interaction of the CD3ε PRS with SH3.1(Nck).

YN370452 Nidufexor 1773489-72-7

Nidufexor (LMB763) is an orally-availablefarnesoid X receptor(FXR) agonist for the research of nonalcoholic steatohepatitis (NASH).

YN310095 Ro 32-0432 hydrochloride 1781828-85-0

Ro 32-0432 hydrochloride is a potent, selective, ATP-competitive and orally activePKCinhibitor. TheIC50 values of Ro 32-0432 hydrochloride forPKCα,PKCβI,PKCβII,PKCγ and PKCεare 9.3nM, 28nM, 30nM, 36.5n...

YN330177 AR-C102222 hydrochloride 1781934-50-6

AR-C102222 hydrochloride is a potent, competitive, orally active and highly selectiveinducible nitric oxide synthase (iNOS)inhibitor, with an IC50 of 37nM. AR-C102222 hydrochloride has antinociception and anti-inflammatory a...