YN321909 Nociceptin(1-7) 178249-42-8

Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potentORL1(NOP)receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia...

YN483007 Salviaflaside 178895-25-5

Salviaflaside is a main bioactive component ofSpica Prunellae.

YN322068 YM158 free base 179102-65-9

YM158 free base is a potent and selectiveLTD4 and TXA2receptorantagonist withpA2values of about 8.87 and 8.81, respectively.

YN300084 SR121566A 180144-61-0

SR121566A is a novel non-peptideGlycoprotein IIb/IIIa(GP IIb-IIIa) antagonist, which can inhibit ADP-, arachidonic acid- and collagen-induced human platelet aggregation with IC50s of 46±7.5, 56±6 and 42±3nM, res...

YN250125 Gatifloxacin sesquihydrate 180200-66-2

Gatifloxacin sesquihydrate (AM-1155; BMS-206584; PD135432) is a potent fluoroquinoloneantibioticwith broad-spectrum antibacterial activity. Gatifloxacin sesquihydrate inhibits bacterialtype II topoisomerases(IC50=13.8 μg/ml fo...

YN330690 Tilmacoxib 180200-68-4

Tilmacoxib (JTE522) is a highly selective, time-dependent and irreversible humanCOX-2 inhibitor with an IC50 of 85nM in an enzyme assay.

YN373296 Ginsenoside F4 181225-33-2

Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing itsapoptosis. Ginsenoside F4 (GF4) inhibits matrix metallo...

YN330322 Valdecoxib 181695-72-7

Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.

YN373987 ZD8321 182073-77-4

ZD8321 is a potent inhibitor of humanNeutrophil elastase(NE) with a Ki of 13±1.7nM.

YN320745 Rupatadine Fumarate 182349-12-8

Rupatadine is an inhibitor of PAFR and histamine (H1) receptor with Ki of 550 nM and 102 nM, respectively.

YN321083 SB225002 182498-32-4

SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.

YN480418 Gemcabene 183293-82-5

Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acu...

YN1710013 MRS1186 183721-03-1

MRS1186 is a potent and selective human Adenosine A3 receptor(hA3AR)antagonist, with aKiof 7.66nM.

YN1710014 MRS1177 183721-13-3

MRS1177 is a potent and selective human Adenosine A3 receptor(hA3AR)antagonist, with aKiof 0.3nM.

YN371606 hDHODH-IN-2 183946-00-1

hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is ahuman dihydroorotate dehydrogenase (hDHODH)inhibitor. hDHODH-IN-1 has anti-inflammatory activity.

YN483623 Benzoylalbiflorin 184103-78-4

Benzoylalbiflorin, a monoterpenoid, and is isolated fromRadix Paeoniae Alba.Radix Paeoniae Albais a traditional Chinese medicine that has been used for the research of rheumatoid arthritis, to alleviate inflammation, amenorrhea, e...

YN380263 Picfeltarraenin IV 184288-35-5

Picfeltarraenin IV, a triterpenoid obtained fromPicriafel-terraeLour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IV can be used for the treatment of herpes infections, cancer and inflammation.

YN484133 NS2 (114-121), Influenza 184763-32-4

NS2 (114-121), Influenza, the 114-121 fragment of influenza nonstructural protein 2 (NS2), is a influenza-derived epitope. NS2 (114-121), Influenza can be used for the research of CD8+cytotoxic T lymphocyte (CTL) in antiviral ...

YN270088 Etanercept 185243-69-0

Etanercept, a dimeric fusion protein that binds TNF, acts as aTNFinhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. E...

YN330663 AF12198 185413-30-3

AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). A...