YN270384 Pralnacasan 192755-52-5

Pralnacasan (VX-740) is a potent, selective, non-peptide and orally activeinterleukin-1β converting enzyme (ICE, caspase 1)inhibitor with a Ki of 1.4nM. Pralnacasan inhibits proinflammatory cytokinesIL-18,IL-1β, and IFN...

YN350068 SB 239063 193551-21-2

SB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.

YN350178 Omtriptolide 195883-06-8

Omtriptolide (PG490-88) is a water soluble derivative prodrug of triptolide purified from the Chinese herb.

YN320177 LM-1484 197506-02-8

LM-1484 is an antagonist of CysLT1 receptor and displays a higher affinity for3H-LTC4 sites.

YN372362 GW311616 hydrochloride 197890-44-1

GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22nM and Kivalue of 0.31nM.

YN370030 CI-1044 197894-84-1

CI-1044 is an orally active PDE4 inhibitor with IC50s of 0.29, 0.08, 0.56, 0.09μM for PDE4A5,PDE4B2,PDE4C2 and PDE4D3, respectively.

YN372361 GW311616 198062-54-3

GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22nM and Kivalue of 0.31nM.

YN330343 Parecoxib 198470-84-7

Parecoxib is a selective COX2 inhibitor.

YN330344 Parecoxib Sodium 198470-85-8

The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue. Adult male Sprague-Dawley rats were administered...

YN371221 MJ33-OH 199106-13-3

MJ33-OH is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversiblephospholipase A2 (PLA2)inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6.

YN410022 INH14 200134-22-1

INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively.

YN372209 Talarozole 201410-53-9

Talarozole (R115866) is an oral systemic all-transretinoic acid metabolism blocking agent (RAMBA)which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits bothCYP26A1 and CYP26B1w...

YN480142 Manitimus 202057-76-9

Manitimus is an inhibitor of dehydroorotate dehydrogenase, and a potent immunosuppressive drug.

YN320871 Bilastine 202189-78-4

Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine and has a rapid onset and prolonged duration of action.

YN330307 Etoricoxib 202409-33-4

Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.

YN320583 NS-2028 204326-43-2

NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30nM and 200nM for basal and NO-stimulated enzyme activity. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of ...

YN250812 Cethromycin 205110-48-1

Cethromycin (ABT-773) is a ketolide antibiotic.

YN483715 Korepimedoside C 205445-00-7

Korepimedoside C (Epimedin I), a flavonol glycoside, is isolated from the aerial parts ofEpimedium koreanumNakai.Epimedium koreanumNakai is a famous Chinese herbal medicine for the research of impotence, osteoporosis, immune suppre...

YN372530 CMI-392 205654-37-1

CMI-392 is a dual5-lipoxygeneseinhibitor and platelet-activating factor (PAF) receptor antagonist with IC50s of 100 and 10nM, respectively.

YN372425 Darunavir 206361-99-1

Darunavir is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.