YN483489 Timosaponin C 185432-00-2

Timosaponin C is isolated fromRhizoma Anemarrhenae. Timosaponin C shows weaker NO inhibition in N9 microglial cells.

YN330596 Ginsenoside Rg5 186763-78-0

Ginsenoside Rg5 is the main component of Red ginseng. Ginsenoside blocks binding ofIGF-1to its receptor with an IC50 of ~90nM. Ginsenoside Rg5 also inhibits the mRNA expression ofCOX-2via suppression of the DNA binding ...

YN321987 Cortistatin-14 186901-48-4

Cortistatin-14, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 shows anticonvulsive, neuroprotective effect and remarkable anti-in...

YN480291 Bimosiamose 187269-40-5

Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectinantagonist with IC50s of 88μM, 20μM, and 86μM forE-selectin,P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects.

YN480292 Bimosiamose disodium 187269-60-9

Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectininhibitor with IC50s of 88μM, 20μM, and 86μM forE-selectin,P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects...

YN484138 Tyrosinase-related Protein 2... 187671-49-4

Tyrosinase-related Protein 2 (TRP-2) (181-188) is a tyrosinase-related protein 2 (TRP-2)-derived peptide, corresponding to residues 180-188. Tyrosinase-related Protein 2 (TRP-2) (181-188) is the major reactive epitope within T...

YN300033 BIO-1211 187735-94-0

BIO-1211 is a highly selective and orally activeα4β1 (VLA-4)inhibitor, with IC50 values of 4nM and 2μM for α4β1 and α4β7, respectively .

YN360570 Carboxyamidotriazole Orotate 187739-60-2

Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor ofnonvoltage-oper...

YN483834 WKYMVM 187986-17-0

WKYMVM is a potent N-formyl peptide receptor (FPR1) and FPRL1/2agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase...

YN410048 AP-1/NF-κB activation in... 188936-12-1

AP-1/NF-κB activation inhibitor 1 is a potentAP-1 and NF-κBmediated transcriptional activation inhibitor (IC50=1μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor...

YN300013 Natalizumab 189261-10-7

Natalizumab is a recombinant, humanized monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multip...

YN330688 FR-188582 189699-82-9

FR-188582 is a highly selective inhibitor ofcyclooxygenase(COX)-2, with an IC50 value of 17nM.

YN330290 Firocoxib 189954-96-9

Firocoxib (ML 1785713) is a potent, selective and orally activeCOX-2 inhibitor with an IC50 of 0.13μM. Firocoxib shows 58-fold more selective forCOX-2than COX-1 (IC50 of 7.5μM). Firocoxib has anti-inflammatory effec...

YN321326 Bepotastine besilate 190786-44-8

Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.

YN330685 RWJ 63556 190967-35-2

RWJ 63556 is an orally activeCOX-2 selective/5-lipoxygenaseinhibitor, with anti-inflammatory activities.

YN480890 K-7174 191089-59-5

K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.

YN480891 K-7174 dihydrochloride 191089-60-8

K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.

YN484273 Diarylalkane derivative 1 191155-65-4

Diarylalkane derivative 1 is used for the research of pancreatitis.

YN430390 Lenalidomide 191732-72-6

Lenalidomide (CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs.

YN320489 BIIL-260 hydrochloride 192581-24-1

BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptorLTB4antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4receptor in a saturable, reversible, ...