YN482828 Ecliptasaponin D 206756-04-9

Ecliptasaponin D is a triterpenoid glucoside isolated fromEclipta alba(L.) Hassk which is the aerial part ofEclipta prostrate.Eclipta prostrateis considered as a nourishing herbal medicine with pleiotropic effects, including anti-inf...

YN484024 Smcy HY Peptide (738-746) 207113-06-2

Smcy HY Peptide (738-746) is a H2-Db-restricted peptide corresponding to amino acids 738-746 of Smcy protein.

YN322019 RS-601 207987-59-5

RS-601 is a novelleukotriene D4 (LTD4)/thromboxane A2 (TxA2)dual receptor antagonist, with antiasthmatic activities.

YN380070 DAPT 208255-80-5

DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.

YN372323 Freselestat 208848-19-5

Freselestat (ONO-6818) is a potent and orally activeneutrophil elastaseinhibitor with a Ki of 12.2nM. Freselestat is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thromb...

YN350028 Neflamapimod 209410-46-8

VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.

YN480419 Gemcabene calcium 209789-08-2

Gemcabene calcium (PD-72953 calcium), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-...

YN330175 GW274150 210354-22-6

GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of humaninducible nitric oxide synthase (iNOS)(IC50=2.19μM;Kd=40nM) and ratiNOS(ED50=1.15μM). GW274150 also displays less potency for ...

YN374145 CP-471474 210755-45-6

CP-471474 is an orally active and panMMPinhibitor, with IC50 values of 1170nM (MMP-1), 0.7nM (MMP-2), 16nM (MMP-3), 13nM (MMP-9) and 0.9nM (MMP-13), respectively.

YN330212 MCC950 210826-40-7

MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively...

YN482272 Cy5.5 210892-23-2

Cy5.5 (Sulfo-Cyanine5.5) is a near-infrared fluorescent dye (Ex=673nM, Em=707nM) used to label biological molecules, such as peptides, proteins, and oligonucleotides.

YN321282 SB-265610 211096-49-0

SB-265610 is a selective, competitive, nonpeptide and allostericCXCR2antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis with IC50s...

YN484003 Interphotoreceptor Retinoid ... 211426-18-5

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP), a 20-residue peptide and a major pathogenic epitope, is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP 161–...

YN321545 Diquafosol tetrasodium 211427-08-6

Diquafosol Tetrasodium, a P2Y2 receptor agonist, is a pharmaceutical drug for the treatment of dry eye disease.

YN481613 Oleanolic acid derivative 2 211516-63-1

Oleanolic acid derivative 2 is an oleanolic acid derivative, which is a novel triterpenoid-steroid hybrid molecule.

YN340071 WHI-P97 211555-05-4

WHI-P97 is a potent inhibitor of JAK-3 with an estimated Ki value of 0.09 μM in modeling studies and a measured IC50 value of 2.5 μM in EGFR kinase inhibition assays.

YN484302 BIBR 1087 SE 212321-78-3

BIBR 1087 SE is an intermediate metabolite of dabigatran etexilate.

YN360310 MRS 1523 212329-37-8

MRS 1523 is a potent and selectiveadenosine A3receptorantagonist with Ki values of 18.9nM and 113nM forhuman and rat A3receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2Arec...

YN483928 Gp100 (25-33), human 212370-40-6

Gp100 (25-33), human (Hgp100 (25-33)) is the amino acids 25-33 fragment of the human melanoma antigen. It is a 9-amino acid (AA) epitope restricted by H-2Db and recognized by the T cells.

YN410150 SN50 213546-53-3

SN50 is a cell permeable inhibitor ofNF-κBtranslocation.