YN440111 RK-24466 213743-31-8

RK-24466 (KIN 001-51) is a potent and selective inhibitor of Lck that inhibits two constructs of the human lck kinase, lck (64-509) and lckcd with IC50 of < 0.001 μM and 0.002 μM, respectively.

YN483207 Jasminoside B 214125-04-9

Jasminoside B is a natural compound isolated from the rhizomes ofAsarum sieboldiiwith immunosuppressive activity.

YN330360 1400W Dihydrochloride 214358-33-5

1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase(iNOS).

YN322063 Neurokinin antagonist 1 214487-45-3

Neurokinin antagonist 1 is aNeurokininantagonist extracted from patent WO1998045262A1.

YN320030 FR167344 free base 215258-13-2

FR167344 free base is an orally active, nonpeptidebradykinin receptor B2antagonist. FR167344 free base shows a high affinity binding to the B2 receptor with an IC50 value of 65nM and no binding affinity for the B1 receptor.

YN350162 RWJ-67657 215303-72-3

RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor with IC50s of 1 and 11μM, respectively. RWJ-67657 displays no activity at p38γ and p38δ, and exhibits cardio protective effe...

YN320158 Bamirastine 215529-47-8

Bamirastine inhibits lig and binding to recombinant human histamine H1receptors (rhH1R) with an IC50 value of 17.3nM.

YN330295 Succinobucol 216167-82-7

AGI-1067 is a novel, phenolic, intra- and extracellular antioxidant that inhibits the expression of a number of proinflammatory genes involved in atherosclerosis.

YN481412 Camobucol 216167-92-9

Camobucol is an orally active, phenolic antioxidant and anti-inflammatory compound with antirheumatic properties.

YN270213 Bz 423 216691-95-1

Bz 423 is a pro-apoptotic 1,4-benzodiazepine with therapeutic properties in murine models of lupus demonstrating selectivity for autoreactive lymphocytes, and activates Bax and Bak.

YN330384 BCX 1470 217099-43-9

BCX 1470 inhibits the esterolytic activity offactor D(IC50=96nM) and C1s(IC50=1.6nM), 3.4- and 200-fold better, respectively, than that of trypsin.

YN330385 BCX 1470 methanesulfonate 217099-44-0

BCX 1470 methanesulfonate inhibits the esterolytic activity offactor D(IC50=96nM) and C1s(IC50=1.6nM), 3.4- and 200-fold better, respectively, than that of trypsin.

YN320539 BX471 217645-70-0

BX471 (ZK-811752) is an orally active, potent and selective non-peptideCCR1antagonist with a Ki of 1nM, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.

YN322054 KP496 217799-03-6

KP496 is a selective, dual antagonist forLeukotriene D4 receptor and Thromboxane A2 receptor.

YN480326 SC-26196 218136-59-5

SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC50=0.2 µM in a rat liver microsomal assay). Antiinflammatory properties.

YN330076 PMX-53 219639-75-5

PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2...

YN361046 ShK-Dap22 220384-25-8

ShK-Dap22 is a potentKv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8nM, 10.5nM, 37nM, and 39nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 cha...

YN371769 AGN194204 220619-73-8

AGN194204 (IRX4204) is an orally active and selectiveRXRagonist withKdvalues 0.4nM, 3.6nM and 3.8nM and EC50s of 0.2nM, 0.8nM and 0.08nM forRXRα,RXRβ and RXRγ, respectively. AGN194204 is inactive agai...

YN300034 Valategrast 220847-86-9

Valategrast (R-411 free base) is a potent and orally activeintegrin α4β1 (VLA-4) and α4β7dual antagonist. Valategrast has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment.

YN330164 GW-406381 221148-46-5

GW406381, a highly selectivecyclooxygenase-2 (COX-2)inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury.