YN321223 Solabegron 252920-94-8

Solabegron (GW 427353) is a selectiveβ3-adrenergic receptoragonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22nM. Solabegron (GW 427353) is being develo...

YN420150 CHIR-98014 252935-94-7

CHIR-98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.

YN481215 (3S,5R)-Pitavastatin calciu... 254452-88-5

(3S,5R)-Pitavastatin cacium is the enantiomer of Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.

YN481214 (3S,5S)-Pitavastatin calciu... 254452-92-1

(3S,5S)-Pitavastatin cacium is the 3-epimer of Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.

YN483036 Kushenol X 254886-77-6

Kushenol X, a flavonoid compound isolated from the roots ofSophora flavescens. Kushenol X is a potentβ-glucuronidase and human carboxylesterase 2 (hCE2)inhibitor with IC50s of 2.07μM and 3.05μM, respectively.

YN420315 Cimiracemoside C 256925-92-5

Cimiracemoside C is an active component ofCimicifuga racemosa, activatesAMPK, has the potential activity against diabetes.

YN321722 Ligustroflavone 260413-62-5

Ligustroflavone, isolated from the leaves of Turpinia montana, shows high antioxidant capacity and is reported to be an AMPK activator.

YN480577 TM-25659 260553-97-7

TM-25659 is atranscriptional co-activator with PDZ-binding motif (TAZ)modulator. Anti-osteoporotic and anti-obesity activities.

YN372390 MB05032 261365-11-1

MB05032 is a special and efficacious GNG inhibitor targeted theAMP binding siteof fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16nM.

YN360028 Soraprazan 261944-46-1

Soraprazan (BYK61359) is a selective, reversible K-competitive inhibitor of theH,K-ATPase(Ki=6.4nM), with an IC50 of 0.19μM in gastric gl and s. Soraprazan binds to the H,K-ATPase with aKdof 28.27nM. Soraprazan sho...

YN370967 CP-532623 261947-38-0

CP-532623 is aCETPinhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties .

YN420214 SB 415286 264218-23-7

SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.

YN1710027 MRS 1754 264622-58-4

MRS 1754 is a selective antagonist radiolig and forA2Badenosine receptor with very low affinity for A1 and A3receptors of both humans and rats.

YN483315 27-Deoxyactein 264624-38-6

27-Deoxyactein is a constituent isolated fromCimicifuga racemosa, prevents TCDD-induced osteoblasts damage. 27-Deoxyactein inhibits increased AhR, CYP1A1 and ERK levels.

YN371171 2-Hydroxy atorvastatin calciu... 265989-46-6

2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8nM.

YN482708 (2S)-2'-Methoxykurarinone 270249-38-2

(2S)-2'-Methoxykurarinone, a compound isolated from the roots ofSophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone...

YN371157 Thiamine monophosphate chlori... 273724-21-3

Thiamine monophosphate chloride (dihydrate) is an endogenous metabolite.

YN372194 Vildagliptin 274901-16-5

Vildagliptin (LAF-237) inhibits DPP?4 with IC50 of 2.3 nM.

YN370332 Nebicapone 274925-86-9

Nebicapone (BIA 3-202), a reversiblecatechol-O-methyltransferase (COMT)inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to ...

YN1720033 Taspoglutide 275371-94-3

Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist developed for treatment of type 2 diabetes, with an EC50 value of 0.06nM.