YN1720045 GLP-2(3-33) 275801-62-2

GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist onGLP-2 receptor(EC50=5.8nM).

YN372634 GW 4064 278779-30-9

GW4064 is an agonist of farnesoid X receptor (FXR) with EC50 of 65 nM in CV1 cell line and displays no activity at other nuclear receptors at concentrations up to 1 μM.

YN360303 Tifenazoxide 279215-43-9

Tifenazoxide (NN414) is a potent, orally active and SUR1/Kir6.2 selectiveKATPchannelsopener. Tifenazoxide has antidiabetic effect, can inhibit glucose stimulated insulin release in vitro and in vivo, and has a beneficial e...

YN481392 Cetilistat 282526-98-1

Cetilistat is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo

YN320001 NPS-2143 284035-33-2

NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM.

YN321298 Fesoterodine 286930-02-7

Fesoterodine is an orally active, nonsubtype selective, competitivemuscarinic receptor (mAChR)antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine is used for the over...

YN321335 Fesoterodine fumarate 286930-03-8

Fesoterodine Fumarate is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.

YN320331 MA-2029 287206-61-5

MA-2029 is a selective, orally active, and competitivemotilin receptorantagonist (IC50=4.9nM). MA-2029 is selective for the motilin receptor over various other receptors and ion channels. MA-2029 may be useful for gastrointesti...

YN360627 Rosuvastatin 287714-41-4

Rosuvastatin (ZD 4522) is a competitive HMG-CoAreductase inhibitor with an IC50 of 11nM. Rosuvastatin potently blockshuman ether-a-go-go related gene (hERG)current with an IC50 of 195nM, delayed cardiac repolarization, an...

YN482818 Cixiophiopogon A 288143-27-1

Cixiophiopogon A, a steroidal glycoside, obtained from the tuberous roots ofOphiopogon japonicus(Liliaceae).

YN370333 Arimoclomol 289893-25-0

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via t...

YN370334 Arimoclomol maleate 289893-26-1

Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the...

YN373005 Netupitant metabolite N-desm... 290296-72-9

N-desmethyl Netupitant is a metabolite of Netupitant, which is an antiemitic drug.

YN483252 Eupteleasaponin I 290809-29-9

Eupteleasaponin I is a component ofEuptelea poly and ra, may has gastroprotective activity.

YN483870 des-​Gln14-​Ghrelin 293735-04-3

des-Gln14-Ghrelin is a second endogenous lig and for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca2+]i in CHO-GHSR62 cells, with an EC50of 2.4nM.

YN372202 SR3335 293753-05-6

SR3335 (ML 176) is a selectiveRORαinverse agonist that directly binds to RORα with a Ki of 220nM.

YN370326 T0901317 293754-55-9

T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively.

YN320246 NKY80 299442-43-6

NKY80 is a potent, selective and non-competitiveadenylyl cyclase (AC)type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone ...

YN370318 Ro 28-1675 300353-13-3

Ro 28-1675 (Ro 0281675) is a potent allosteric GK activator with a SC1.5 value of 0.24± 0.0019 uM. The R stereoisomer Ro 28-1675 activated GK with a SC1.5 of 0.24 uM, while the S isomer did not activated GK up to 10 uM....

YN370212 BMS-309403 300657-03-8

BMS309403 is a small-molecule FABP4 inhibitor with nM affinity (Kd=4 nM for FABP4) and >100-fold selectivity against FABP5 as well as the heart isoform FABP3.