YN380273 Galanthamine N-Oxide 134332-50-6

Galanthamine N-Oxide is an alkaloid obtained from the bulbs ofZephyranthes concolor. Galanthamine N-Oxide inhibits electric eelacetylcholinesterase (AChE)with an EC50 of 26.2μM. Galanthamine N-Oxide is a prominent inhibitor...

YN370268 CA-074 134448-10-5

CA-074 is a potent inhibitor ofcathepsin Bwith a Ki of 2 to 5nM.

YN370082 3-O-Methyltolcapone 134612-80-9

3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkin...

YN380306 β-Amyloid (12-20) 134649-29-9

β-Amyloid (12-20) is a peptide fragment of β-Amyloid.

YN320135 8-M-PDOT 134865-70-6

8-M-PDOT (AH-002) is a selectivemelatonin MT2 receptoragonist. 8-M-PDOT is 5.2-fold selective forMT2over MT1 receptors. 8-M-PDOT binds human recombinantMT2 and MT2 receptors with pKi values of 8.23 and 8.95 re...

YN320059 4-P-PDOT 134865-74-0

4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2)antagonist. 4-P-PDOT is >300-fold more selective forMT2than MT1. 4-P-PDOT significantly counteracts Melatonin-mediated antioxidant effects (GSH...

YN320771 DuP 734 135135-87-4

DuP 734 is asigma receptorantagonist. DuP 734 is a selective and potent sigma and 5-HT2 receptor lig and with weak affinity for D2 receptors. DuP 734 may have antipsychotic activity without the liability of motor side effects ...

YN360838 Acetamiprid 135410-20-7

Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is anicotinic acetylcholine receptor (nAChR)agonist, and is shown to be associated with neuromuscular and reproductive disorders.

YN360638 Coluracetam 135463-81-9

Coluracetam (BCI-540, MKC-231) is a nootropic belonging to the racetam family of drugs with cognitive enhancing and neuroprotective effects.

YN321837 MDL 29913 135721-56-1

MDL 29913, a cyclic pseudopeptide, is a competitiveNK2tachykinin receptor selective antagonist, with a pA2of 8.66.

YN483951 Galanin (1-19), human 136005-51-1

Galanin (1-19), human is the 1-19 fragment of the human galanin. Galanin (GAL) is a widely distributed neuropeptide with diverse biological effectsincluding modulation of hormone release, antinociception and modification of feeding b...

YN1730033 Rolofylline 136199-02-5

Rolofylline (KW-3902) is a potent, selectiveadenosine A1 receptorantagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the...

YN380104 Rasagiline 136236-51-6

Rasagiline is a novel selective and irreversible MAO-B propargylamine inhibitor with in vitro IC50s of 4.43 nM and 412 nM for MAO-B and MAO-A, respectively.

YN370409 DPP-IV-IN-2 136259-18-2

DPP-IV-IN-2 is an inhibitor of bothdipeptidyl peptidase IV(DPIV) and DP8/9with IC50s of 0.1 and 0.95μM, respectively.

YN321121 Tiotropium Bromide 136310-93-5

Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine lig and and subsequent opening of the lig and -gated ion channel.

YN380161 Duloxetine hydrochloride 136434-34-9

Duloxetine HCl is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).

YN322014 Temiverine hydrochloride 136529-33-4

Temiverine hydrochloride is a synthesized drug that is expected to have anticholinergic action.

YN482561 Timosaponin BII 136656-07-0

Timosaponin BII is a steroid saponin found in the rhizomes ofAnemarrhena asphodeloides. Timosaponin BII has neuronal protective and anti-inflammatory effects and antioxidant property.

YN380175 Clomipramine D3 136765-29-2

Clomipramine D3 is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Kiof 0.14, 54 and 3nM, respectively.

YN1730071 Haloperidol (D4') 136765-35-0

Haloperidol D4' is deuterium labeled haloperidol, and the latter is a potentdopamine D2 receptorantagonist.