YN482882 6"-O-Apiosyl-5-O-Methylvis... 139446-82-5

6”-O-Apiosyl-5-O-Methylvisammioside is one of the components of the traditional Chinese medicineKang-Jing.

YN320165 Sigma-LIGAND-1 139652-01-0

Sigma-LIG and -1 is a selectivesigma receptorlig and , has receptorIC50s of 16nM at the DTG site, 19nM at the PPP site, and a Ki of 4000nM at the dopamine D2 receptor.

YN360139 CGP52432 139667-74-6

CGP52432 is aGABABreceptorantagonist, with an IC50 of 85nM.

YN350258 Tenuifoliside A 139726-35-5

Tenuifoliside A is isolated fromPolygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through theERK/CREB/BDNFsignal ...

YN483174 Tenuifoliside B 139726-36-6

Tenuifoliside B, a component isolated from Polygalae Radix, inhibits potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment. Tenuifoliside B shows potential cognitive improvement and cerebral protecti...

YN482663 3',6-Disinapoylsucrose 139891-98-8

3',6-Disinapoylsucrose, the index component of Yuanzhi (Polygala tenuifoliaWilld), possesses potent antioxidant activity and antidepressant effect.

YN360073 ATPA 140158-50-5

ATPA is a selective glutamate receptorGluR5activator with EC50s of 0.66, 9.5, 1.4, 23, 32, 18, and 14μM for GluR5wt, GluR5(S741M), GluR5(S721T), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and Glu...

YN360583 (S)-(-)-5-Fluorowillardiine 140187-23-1

(S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist.

YN340040 RSVA405 140405-36-3

RSVA405 is a potent, orally active activator ofAMPK, with an EC50 of 1μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibitsmTOR, and promotesautophagyto increase Aβ degradation. RSVA405 ha...

YN320734 Xanomeline oxalate 141064-23-5

Xanomeline oxalate (LY246708 oxalate) is a potent and selectivemuscarinic receptoragonist (SMRA) and stimulates phosphoinositide hydrolysis in vivo. Xanomeline oxalate can be used for the research of Alzheimer’s disease.

YN360351 PEPA 141286-78-4

PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.

YN321889 GR 94800 141636-65-9

GR 94800 is a potent and selectiveNK2receptor peptide antagonist, with pKBvalues of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3receptors, respectively.

YN321798 Endomorphin 2 141801-26-5

Endomorphin 2, a high affinity, highly selective agonist of theμ-opioid receptor, displays reasonable affinities for kappa3binding sites, withKivalue between 20 and 30nM.

YN320309 Saredutant 142001-63-6

Saredutant is a selectiveNK2 receptorantagonist.

YN360657 L-701324 142326-59-8

L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.

YN440020 Rp-cAMPS sodium salt 142439-94-9

Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependentPKA I and II(Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to ...

YN370062 Sp-cAMPS sodium salt 142439-95-0

Sp-cAMPS sodium salt, a cAMP analog, is potent activator of cAMP-dependentPKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitivephosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAM...

YN320025 5-HT1A modulator 1 142477-34-7

5-HT1A modulator 1 displays very high affinities for the5HT1A,adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3nM, 10 ± 3nM and 40 ±9nM, respectively.

YN321970 Gluten Exorphin C 142479-62-7

Gluten exorphin C is an opioid peptide derived from wheat gluten. ItsIC50 values are 40μM and 13.5μM forμ opioid and δ opioidactivities in the GPI and MVD assays, respectively.

YN321062 IRL-1620 142569-99-1

IRL-1620 is a potent and selectiveendothelin receptor type B (ETB)agonist with a Ki of 16 pM.