YN483770 PACAP (1-38), human, ovin... 137061-48-4

PACAP 1-38 is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.

YN483825 Spinorphin 137201-62-8

Spinorphin is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect.

YN484266 Urinary Incontinence-Target... 137315-05-0

Urinary Incontinence-Targeting Compound 1 is a sulfonanilide derivative, used in the research of urinary incontinence.

YN330053 Nω-Propyl-L-arginine 137361-05-8

Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase(nNOS), with a Ki of 57nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for...

YN1730008 Dihydrexidine hydrochloride 137417-08-4

Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacyD1-like dopamine receptor (D1/D5)agonist, with an IC50 of 10nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent anti...

YN321890 GR 64349 137593-52-3

GR 64349 is a potent and highly selectiveNK2receptor peptide antagonist, with an EC50of 3.7nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3receptors, respectively.

YN321108 Agomelatine 138112-76-2

Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.

YN360061 (RS)-(Tetrazol-5-yl)glycine 138199-51-6

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selectiveN-methyl-D-aspartate (NMDA)receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99nM, 1.7μM for GluN1/GluN2D and Glu...

YN481876 Imidacloprid 138261-41-3

Imidacloprid is a nicotinic acetylcholine receptor (nAChR) agonist with potent insecticidal activity.

YN321099 BD-1047 dihydrobromide 138356-21-5

BD-1047 dihydrobromide (HBr) is a selective functional antagonist of sigma-1 (σ1) receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.

YN310249 Ro 31-8220 mesylate 138489-18-6

Bisindolylmaleimide IX (Ro 31-8220 Mesylate) is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent in...

YN321827 Galantide 138579-66-5

Galantide, a non-specificgalanin receptorantagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (KD<0.1nM and ~6nM) in the rat hypothalamus. Galanti...

YN483997 PACAP-38 (31-38), human, ... 138764-85-9

PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP is a potent activator of cAMP formation.

YN321131 Ziprasidone hydrochloride mon... 138982-67-9

Ziprasidone (CP 88059) hydrochloride monohydrate, an antipsychotic agent, is an orally active combined5-HT (serotonin) and dopamine receptorantagonist. Ziprasidone hydrochloride monohydrate has high affinity for rat (Ki: 3.4nM)/huma...

YN322000 [Lys8, Lys9]-Neurotensin (8... 139026-64-5

[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptorsNTS1 and NTS2, with Ki values of 0.33nM and 0.95nM for hNTS1 and hNT...

YN321885 JMV 449 139026-66-7

JMV 449 is a potentneurotensin receptoragonist. JMV 449 shows an IC50 of 0.5nM in binding to mouse brain membranes and an EC50of 1.9nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypoth...

YN360070 L-689560 139051-78-8

L-689560 is a potentN-methyl-D-aspartate (NMDA)receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled lig and in binding studies and used for study the roles of NMDA receptors in no...

YN1730084 ZM241385 139180-30-6

ZM-241385?is a high affinity antagonist ligand selective for the adenosine A2A receptor.

YN320770 Panamesine 139225-22-2

Panamesine (EMD 57445) is asigma receptorlig and , which has a high affinity (IC506nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent.

YN320935 Volinanserin 139290-65-6

Volinanserin is a potent and selective antagonist of 5-HT2receptor, with a Ki of 0.36nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2receptors. Volinanserin has antipsychotic activity.