YN320243 GR 113808 144625-51-4

GR 113808 is a potent and highly selective5-HT4receptorantagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3receptors.

YN360669 Perzinfotel 144912-63-0

Perzinfotel (EAA-090) is a potent, selective, and competitiveNMDA receptorantagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity (IC50=30nM) for the glutamate site.

YN361037 ω-Agatoxin IVA 145017-83-0

ω-Agatoxin IVA is a potent, selectiveP/Q type Ca2+channelblocker with IC50s of 2nM and 90nM forP-type and Q-type Ca2+channels, respectively. ω-Agatoxin IVA (IC50, 30-225nM) inhibits glutamate exocytosis and calciu...

YN270568 Hydrolyzed Fumonisin B1 145040-09-1

Hydrolyzed Fumonisin B1 (Aminopentol) is the backbone and main hydrolysis product of the mycotoxin fumonisin B1 (FB1), can weakly inhibit ceramide synthase.

YN321105 Dexmedetomidine hydrochloride 145108-58-3

Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.

YN321430 Rizatriptan benzoate 145202-66-0

Rizatriptan Benzoate is an agonist at serotonin 5-HT1B and 5-HT1D receptors, used to treat acute migraine attacks.

YN320110 Clobenpropit dihydrobromide 145231-35-2

Clobenpropit dihydrobromide is a potenthistamine H3Rantagonist/inverse agonist with apEC50of 8.07 for histamine H3LR. Clobenpropit dihydrobromide acts as partial agonist athistamine H4receptors (Ki13nM). Clobenpropit dihydrobro...

YN321781 Cetrorelix Acetate 145672-81-7

Cetrorelix Acetate (SB-75 acetate) is a potent gonadotropin-releasing hormone(GnRH)receptor antagonist with an IC50 of 1.21nM.

YN361048 Margatoxin 145808-47-5

Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor ofKv1.3(Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom ...

YN360830 Tiagabine hydrochloride hydra... 145821-57-4

Tiagabine hydrochloride hydrate is a potent and selectiveGABA uptakeinhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively.

YN360829 Tiagabine hydrochloride 145821-59-6

Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.

YN483783 Mas7 145854-59-7

Mas7 (Mastoparan 7), a structural analogue of mastoparan, is an activator of heterotrimericGi proteins and its downstream effectors.

YN340043 CGP52411 145915-58-8

CGP52411 (DAPH) is a high selective, potent, orally active and ATP-competitiveEGFRinhibitor with an IC50 of 0.3μM. CGP52411 blocks the toxic influx of Ca2+ions into neuronal cells, and dramatic inhibits and rever...

YN320500 OPC-14523 free base 145969-30-8

OPC-14523 free base is an orally activesigma and 5-HT1A receptoragonist, with high affinity for sigma receptors (σ1/2IC50=47/56nM), the 5-HT1A receptor (IC50=2.3nM), and the 5-HT transporter (IC50=80nM). OPC-14523 ...

YN320501 OPC-14523 hydrochloride 145969-31-9

OPC-14523 hydrochloride is an orally activesigma and 5-HT1A receptoragonist, with high affinity for sigma receptors (σ1/2IC50=47/56nM), the 5-HT1A receptor (IC50=2.3nM), and the 5-HT transporter (IC50=80nM). OPC-14...

YN370065 MSDC 0160 146062-49-9

MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulatinginsulin sensitizer and a modulator ofmitochondrial pyruvate carrier (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabeti...

YN320621 DHPG 146255-66-5

DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist ofgroup I mGluR(mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs. DHPG ((RS)-3,5-DHPG) is also ...

YN320280 Meclinertant 146362-70-1

Meclinertant (SR 48692) is a potent, selective, nonpeptide and orally activeneurotensin receptor 1 (NTS1)antagonist. In human colon carcinoma (HT-29) cells, Meclinertant competitively antagonizes neurotensin-induced intracellula...

YN322046 CDD0102 146422-58-4

CDD0102 is a potentM1Muscarinic receptoragonist.

YN320036 (RS)-MCPG 146669-29-6

(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group IImetabotropic glutamate receptor (mGluR)antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal...