YN270613 Infliximab 170277-31-3

Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds toTNF-α. Infliximab prevents the interaction ofTNF-αwith TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for auto...

YN360672 U-101017 170568-47-5

U-101017 is a partial agonist ofbenzodiazepine receptor and GABAA receptor, with anxiolytic effects.

YN321796 Nociceptin 170713-75-4

Nociceptin, a heptadecapeptide, is the endogenous lig and of the nociceptin receptor, acting as a potent anti-analgesic.

YN250027 Aprepitant 170729-80-3

Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM.

YN483782 Astressin 170809-51-5

Astressin is a potent corticotropin releasing factor (CRF) antagonist.

YN320037 E4CPG 170846-89-6

E4CPG is a group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG .

YN1730066 Sonepiprazole 170858-33-0

Sonepiprazole (PNU-101387G) is a selectiveD4 dopamineantagonist with Kis of 3.6, 10.1, 5147, and 7430nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively.

YN320297 Donitriptan 170912-52-4

Donitriptan is a potent, high efficacy agonist at5-HT1B/1Dreceptors withpKis of 9.4 and 9.3, respectively.

YN320130 EGLU 170984-72-2

EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a potent and competitivemGluR-2receptor antagonist. EGLU interacts with (lS,3S)-ACPD-sensitive site with aKdvalue of 66μM. EGLU is an antidepressant agent.

YN321894 Urocortin, rat 171543-83-2

Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenousCRFRagonist with Kis of 13nM, 1.5nM, and 0.97nM forhuman CRF1,rat CRF2α and mouse CRF2β, respectively.

YN360566 Trans (2,3)-Dihydrotetrabena... 171598-74-6

Trans (2,3)-Dihydrotetrabenazine ((2R,3R,11bR)-rel-Dihydrotetrabenazine), a metabolite of Tetrabenazine, shows remarkable inhibition activity onvesicular monoamine transporter (VMAT2).

YN310374 PKC β pseudosubstrate 172308-76-8

PKC β pseudosubstrate is a selective cell-permeable inhibitor ofPKC.

YN320862 Fosaprepitant 172673-20-0

Fosaprepitant (L785298) is a prodrug of Aprepitant (HY-10052). Fosaprepitant is aneurokinin-1 receptorantagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting.

YN321919 DPDPE TFA 172888-59-4

DPDPE TFA, an opioid peptide, is a selectiveδ-opioid receptor (DOR)agonist with anticonvulsant effects.

YN370100 2-PMPA 173039-10-6

2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM.

YN481409 Fabomotizole 173352-21-1

Fabomotizole (CM346) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF a...

YN481410 Fabomotizole hydrochloride 173352-39-1

Fabomotizole hydrochloride exhibits anxiolytic and neuroprotective properties. Fabomotizole hydrochloride is a potent sigma1-receptor agonist with IC50 of 7.1 µM and Ki of 5.9 µM.

YN360656 SYM2206 173952-44-8

SYM2206 is a potent and non-competitiveAMPA receptorantagonist, with an IC50 of 1.6μM. SYM2206 blocks Nav1.6-mediated persistent currents.

YN360402 SDZ 220-581 174575-17-8

SDZ 220-581 is an orally active, potent, competitiveNMDA receptorantagonist withpKivalue of 7.7.

YN321022 SB-222200 174635-69-9

SB-222200 is a potent, selective, orally active and blood-brain barrier (BBB) penetrantNK-3 receptorantagonist. SB-222200 is developed for central nervous system (CNS) disorders.