YN320985 6-Iodopravadoline 164178-33-0

6-Iodopravadoline (AM630) is a selective cannabinoid CB2 receptor antagonist with Ki of 31.2 nM.

YN320916 Cutamesine 165377-43-5

Cutamesine (SA4503; AGY-94806) is a selective sigma 1 receptor(σ1R) agonist; high affinity for the sigma 1 receptor subtype labeled by (+)-[3H]pentazocine (IC50= 17.4±1.9nM); 100-fold less affinity for the sigma 2 receptor.

YN320743 Cutamesine dihydrochloride 165377-44-6

Cutamesine dihydrochloride (SA4503 dihydrochloride; AGY94806 dihydrochloride) is a potentSigma 1receptor agonist with an IC50 of 17.4nM in guinea pig brain membranes.

YN380291 β-Amyloid (1-42), rat 166090-74-0

β-Amyloid (1-42), rat is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.

YN480258 Fmoc-1,6-diaminohexane 166410-37-3

Fmoc-1,6-diaminohexane is an analog of Osw-1 which has the potential for Alzheimer's disease and cancer treatment from patent US 20140135279 A1.

YN320720 3-Hydroxy agomelatine 166526-99-4

3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a5-HT2Creceptorantagonist with an IC50 of 3.2μM and a Ki of 1.8μM.

YN320721 7-Desmethyl-3-hydroxyagomelat... 166527-00-0

7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine. Agomelatine is amelatonergic(MT1 and MT2) agonist and serotonergic(5HT2C) antagonist.

YN360671 GV-196771A 166974-23-8

GV-196771A is the sodium salt form of GV196771, is an NMDA receptorantagonist.

YN380278 Autocamtide-2-related inhibit... 167114-91-2

Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor ofCaMKIIwith an IC50 of 40nM.

YN321349 Flibanserin 167933-07-5

Flibanserin is a nonhormonal, centrally acting molecule that acts as an agonist at postsynaptic 5-HT1A receptors and as an antagonist at 5-HT2A receptors.

YN330242 Disufenton sodium 168021-79-2

NXY-059 is a novel nitrone, shows efficacious neuroprotective effects. Phase 3.

YN361049 Agitoxin-2 168147-41-9

Agitoxin-2 is aK+channel inhibitor, with IC50 values of 201 pM and 144 pM for mKV1.3 and mKV1.1, respectively).

YN320551 Vofopitant dihydrochloride 168266-51-1

Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values. of 9.5 and 10.6 in rat and ...

YN320550 Vofopitant 168266-90-8

Vofopitant is potenttachykinin NK1receptorantagonist, withpKis of 10.6, 9.5, and 9.8 for human, rat and ferret NK1receptor, respectively.

YN480179 Heterocyclyl carbamate deriva... 168830-01-1

Heterocyclyl carbamate derivative 1 is a heterocyclyl carbamate derivative that may be used for the research of inflammatory and neurological diseases.

YN372234 Afegostat 169105-89-9

Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.

YN320219 (2R,4R)-APDC 169209-63-6

(2R,4R)-APDC is a selective group II metabotropic glutamate receptors(mGluRs)agonist. (2R,4R)-APDC has anticonvulsant and neuroprotective effects.

YN360471 Ro 25-6981 169274-78-6

Ro 25-6981 is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC50 values are 0.009 and 52μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A res...

YN321309 Alvimopan dihydrate 170098-38-1

Alvimopan dihydrate is a novel, orally available peripherally restricted opioid antagonist with low systemic absorption. It accelerates the gastrointestinal recovery period with most common side effects in chronic pain patients with OBD...

YN321555 Imidafenacin 170105-16-5

Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM).