YN320205 Blarcamesine hydrochloride 195615-84-0

Anavex 2-73, an aminotetrahydrofuran derivative, is a mixed muscarinic and sigma-1/σ_{1 Receptor} agonist with IC50 of 0.86 μM.

YN1730116 Exendin (5-39) 196109-27-0

Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats.

YN483864 Prosaptide Tx14(A) 196391-82-9

Prosaptide Tx14(A), a prosaposin-derived peptide, is a potentGPR37L1 and GPR37agonist with EC50s of 5 and 7nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells.

YN321325 Ramelteon 196597-26-9

Ramelteon is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively.

YN290360 GW1929 196808-24-9

GW1929 is a potentPPAR-γagonist, with a pKi of 8.84 for humanPPAR-γ, and pEC50s of 8.56 and 8.27 for humanPPAR-γ and murinePPAR-γ, respectively.

YN270606 NTR 368 197230-90-3

NTR 368 is a peptide derived from p75 neurotrophin receptor (p75NTR) corresponding to residues 368-381 of the human receptor. NTR 368 has helix forming propensity in the presence of micellar lipid. NTR 368 is a potent inducer o...

YN320326 LY367385 198419-91-9

LY367385 is a highly potent and selectivemGluR1aantagonist. LY367385 has an IC50 of 8.8μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100μM for mGlu5a. LY367385 has neuroprotectiv...

YN480781 Ro 61-8048 199666-03-0

Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively.

YN321330 Paliperidone palmitate 199739-10-1

Paliperidone palmitate (9-Hydroxyrisperidone palmitate), an atypical long-acting antipsychotic agent, is an ester prodrug of Paliperidone. Paliperidone is adopamineantagonist and 5-HT2Aantagonist of the atypical antipsychotic class....

YN320982 RS-127445 hydrochloride 199864-86-3

RS-127445 hydrochloride is a selective, high affinity, orally bioavailable5-HT2Breceptorantagonist with a pKi of 9.5. RS-127445 hydrochloride shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ...

YN320983 RS-127445 199864-87-4

RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.

YN270340 Omigapil maleate 200189-97-5

Omigapil maleate, an orally bioavailableGAPDH nitrosylationinhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil maleate has the potential for the research of Alzheim...

YN320236 SB 243213 200940-22-3

SB 243213 is an orally active, selective and high-affinity5-HT2Creceptorantagonist with a pKi of 9.37 and apKbof 9.8 for human 5-HT2Creceptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotra...

YN320234 SB 243213 hydrochloride 200940-23-4

SB 243213 hydrochloride is an orally active, selective and high-affinity5-HT2Creceptorantagonist with a pKi of 9.37 and apKbof 9.8 for human 5-HT2Creceptor. SB 243213 hydrochloride shows greater than a 100-fold selectivity o...

YN321905 Ac-RYYRWK-NH2 200959-47-3

Ac-RYYRWK-NH2 is a potent and selective partial agonist for thenociceptin receptor (NOP), [3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with aKdof 0.071nM, but has no affinity for µ-, κ- or δ-opioid ...

YN321908 Ac-RYYRIK-NH2 200959-48-4

Ac-RYYRIK-NH2 is a potent and partial agonist onORL1transfected in CHO cells (Kd=1.5nM) and behaves as a endogenous lig and of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein ...

YN320967 SB-269970 201038-74-6

SB269970 is a5-HT7 receptorantagonist withpKiof 8.3, exhibits >50-fold selectivity against other receptors.

YN380279 Autocamtide-2-related inhibit... 201422-04-0

Autocamtide-2-related inhibitory peptide, myristoylated is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor ofCaMKIIwith an IC50 of 40...

YN321300 LY341495 201943-63-7

LY341495 is ametabotropic glutamate receptor (mGluR)antagonist with IC50s of 21nM, 14nM, 7.8μM, 8.2μM, 170nM, 990nM, 22μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors, respectively..

YN480365 GET73 202402-01-5

GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus .