YN320740 AM281 202463-68-1

AM281 is a selectiveCB1 receptorantagonist with an IC50 of 9.91nM. AM281 inhibits CB2 receptor with an IC50 of 13000nM.

YN380093 (S)-Rasagiline mesylate 202464-88-8

(S)-Rasagiline (TVP1022) mesylate is the S-isomer of rasagiline, which is an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor.

YN320851 Ro 04-6790 202466-68-0

Ro 04-6790 is a potent, competitive and selective5-HT6receptor antagonist with pKi values. of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors.

YN480740 DMP 696 202578-52-7

DMP 696 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist, used for the treatment of anxiety and depression.

YN1730010 AHN 1-055 hydrochloride 202646-03-5

AHN 1-055 hydrochloride is adopamine uptakeinhibitor, with an IC50 of 71nM. AHN 1-055 hydrochloride binds with high affinity to thedopamine transporter (DAT) and may serve as leads for the development of agentia to treat cocain...

YN321927 Orexin B, rat, mouse 202801-92-1

Orexin B, rat, mouse is an endogenous agonist atOrexinreceptor with Kis of 420 and 36nM for OX1 and OX2, respectively.

YN360098 MRZ 2-514 202808-11-5

MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor(glycineB), with Kiof 33μM.

YN360221 BMS-191011 202821-81-6

BMS-191011 (BMS-A) is an opener of the large-conductance,Ca2+-activated potassium (maxi-K) channel, effective in stroke models.

YN360090 Ralfinamide mesylate 202825-45-4

Ralfinamide mesylate (FCE-26742A mesylate) is an orally availableNa+channelblocker derived from α-aminoamide, with function of suppressing pain.

YN380148 Safinamide mesylate 202825-46-5

Safinamide Mesylate is mesylate salt of Safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. Phase 3.

YN361032 SNX-482 203460-30-4

SNX-482, a peptidyl toxin of the spiderHysterocrates gigas, is a potent, high affinity, selective and voltage-dependent R-typeCaV2.3 channelblocker with an IC50 of 30nM. SNX-482 has antinociceptive effect .

YN270253 Indibulin 204205-90-3

Indibulin (ZIO 301, D 24851, Zybulin) is an orally applied inhibitor of tubulin assembly with potent anticancer activity. Indibulin induces mitotic arrest and apoptosis.

YN1730086 Tecadenoson 204512-90-3

Tecadenoson (CVT-510) is a selectiveA1 adenosine receptoragonist.

YN320886 Talnetant hydrochloride 204519-66-4

Talnetant Hcl(SB 223412 Hcl) is a potent and selective NK3 receptor antagonist(ki=1.4nM, hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM...

YN320092 Olcegepant 204697-65-4

Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of thecalcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03nM and Kiof 14.4 pM for human CGRP.

YN320169 NRA-0160 204718-47-8

NRA-0160 is a selectivedopamine D4 receptorantagonist, with aKivalue of 0.48nM and with negligible affinity fordopamine D2 receptor(Ki: >10000nM),D3 receptor(Ki: 39nM), rat5-HT2A receptor(Ki: 180nM) and ratα1 adrenocep...

YN320278 Nemifitide diTFA 204992-09-6

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF). Nemifitide diTFA can ...

YN380015 2614W94 205187-35-5

2614W94 is a selective, reversible inhibitor ofmonoamine oxidase-Awith a competitive mechanism of inhibition and IC50 of 5nM and Kiof 1.6nM with serotonin as substrate.

YN380004 CX-157 205187-53-7

CX-157 is a reversible inhibitor ofmonoamine oxidase-A(MAO-A) with an EC50 of 19.3 ng/mL.

YN360185 DL-TBOA 205309-81-5

DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70μM, 6μM and 6μM forexcitatory amino acid transporter-1 (EAAT1),EAAT2 and EAAT3, respectively. DL-TBOA in...