YN270602 Z-LEHD-FMK 210345-04-3

Z-LEHD-FMK is a selective and irreversible inhibitor ofcaspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma ...

YN330175 GW274150 210354-22-6

GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of humaninducible nitric oxide synthase (iNOS)(IC50=2.19μM;Kd=40nM) and ratiNOS(ED50=1.15μM). GW274150 also displays less potency for ...

YN321262 Org-12962 hydrochloride 210821-63-9

Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2Creceptor agonist and exhibitspEC50values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in...

YN482272 Cy5.5 210892-23-2

Cy5.5 (Sulfo-Cyanine5.5) is a near-infrared fluorescent dye (Ex=673nM, Em=707nM) used to label biological molecules, such as peptides, proteins, and oligonucleotides.

YN321900 CART(62-76)(human,rat) 210978-19-1

CART(62-76)(human,rat) is a neuropeptide (62-76 residues of the CART peptide) with neurotransmitter-like effects. CART(62-76)(human,rat) can modulate the activity of striatal noradrenergic and corticostriatal and hypothalami...

YN360426 LY-404187 211311-95-4

LY-404187 is a potent, selective and centrally active positive allosteric modulator ofAMPA receptors, with theEC50s of 5.65, 0.15, 1.44, 1.66 and 0.21 µM forGluR1i,GluR2i,GluR2o,GluR3i and GluR4i, respectively. LY-...

YN360239 Farampator 211735-76-1

Farampator (CX-691;Org24448) is anAMPAreceptor positive modulator.

YN481325 ZT-1a 212135-62-1

ZT-1a is a potent, non-ATP-competitive and selectiveSPAKinhibitor. ZT-1a inhibits SPAK activity with IC50s of 44.3, 35.0, 46.7μM at ATP concentrations of 0.01, 0.1 and 1 mM, respectively.

YN320524 BAY 38-7271 212188-60-8

BAY 38-7271 is selective and highly potent and cannabinoidCB1/CB2receptoragonist, with Kis of 1.85nM and 5.96nM for recombinant human CB1receptor and CB2receptor, respectively. BAY 38-7271 has strong neuroprotective...

YN360310 MRS 1523 212329-37-8

MRS 1523 is a potent and selectiveadenosine A3receptorantagonist with Ki values of 18.9nM and 113nM forhuman and rat A3receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2Arec...

YN483813 Nocistatin(human) 212609-11-5

Nocistatin (human) blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostagl and in E2.

YN320310 Cipralisant 213027-19-1

Cipralisant is a potent and selectivehistamine H3 receptorantagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47nM for rat histamine H3 receptor; Cipralisant has the potential...

YN481444 UPF-648 213400-34-1

UPF-648 is a potent kynurenine 3-monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO inhibition); ineffective at blocking KAT activity.

YN320576 CYT-1010 213769-33-6

CYT-1010 is amu-opioid receptoragonist extracted from patent WO2013173730A2, with EC50s of 13.1nM and 0.0053nM on beta-arrestin recruitment and inhibition of cAMP production, respectively.

YN483859 CART(55-102)(human) 214050-22-3

CART(55-102)(human) is an endogenous satiety factor with potent appetite-suppressing activity. CART(55-102)(human) is closely associated with leptin and neuropeptide Y.

YN322045 MEN11467 214487-46-4

MEN11467 is a selective and orally- effective peptidomimetictachykinin NK1receptorantagonist.

YN322029 Lusaperidone 214548-46-6

Lusaperidone (R107474) is an α2adrenergic receptorantagonist with Kis of 0.13 and 0.15nM for α2A and α2C, respectively.

YN320174 YM-58790 214558-72-2

YM-58790 is a potent antagonist ofM3 muscarinic receptor, with Kiof 15nM.

YN483904 Prolactin Releasing Peptide... 215510-22-8

Prolactin Releasing Peptide (1-31), human is a high affinityGPR10lig and that cause the release of the prolactin. Human and rat Prolactin Releasing Peptide (1-31) binds to GPR10 with Kis of 1.03 and 0.33nM, respectively.

YN1730046 SB269652 215802-15-6

SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.